ASD

GO:0006469 negative regulation of protein kinase activity (125)

GeneInput weightStandardRank
PPP2CA--20
RGS4--178
GNAQ--189
APC0.251266
LRP6--279
NF10.251372
DUSP8--438
TRIB2--472
MAPK8IP1--1605
UCHL1--1675
SPRED2--811
DRD10.251899
SPRED1--962
AKT10.2511020
DRD50.2511103
PKIA--1118
BMP7--1137
CDKN1B--1162
PPP2R1A--1163
PTEN1.011389
SPRY2--1454
THY1--1580
SRCIN1--1738
PDPK1--1740
YWHAG--1857
SPECC1L--1912
DUSP5--2022
GPS1--2023
ABL1--2404
DUSP6--2466
HMGCR--2526
PDCD4--2707
LATS1--2781
NR2F2--2941
SPRY4--3196
TRIB1--3431
DAB2IP--3482
DUSP1--3785
DUSP4--4019
PRKAG2--14212
PAK2--4270
SH3BP5--4481
INPPL1--4681
MEN1--14917
RGS2--5095
DUSP10--5172
GADD45A--5185
DUSP16--5189
MYOCD--5907
HEXIM1--5982
NF2--15991
ADIPOQ0.2516032
DUSP19--6060
TFAP4--6377
BMP4--16499
PRKCD--6504
ERRFI1--6649
RB1--16804
ILK--7305
CRIPAK--7596
CDKN1A--7714
ZFYVE28--7781
HIPK3--8282
GADD45B--8312
ADORA2A0.2518408
DUSP3--8506
DUSP2--8596
DUSP7--8625
GSTP10.2518742
NUP62--18755
PTPRJ--19136
TSC20.2519351
LRP5--19420
LATS2--9736
LAX1--10483
DEPTOR--10635
SPRY1--10636
DBNDD2--10675
IL1B--110818
PYDC1--11053
PKIB--11430
TAF7--11434
ZNF675--11676
STK380.25111822
SPRED3--12062
IL6--112695
RGS14--12999
AKT1S1--13569
DUSP9--13685
MBIP--14010
IRAK3--14633
CAV3--115414
GPS2--17956
PSEN1--18523
TP73--18810
DVL1--18924
ZGPAT--20366
PRKRIP1--20422
CDKN2A--120587
TRIB3--20863
CBLC--21497
HEXIM2--21545
PTPRC--21546
FABP4--21888
PKIG--22117
SNX6--22713
IBTK--22790
GNB2L1--23282
HSPB1--123318
RGS3--23349
APOE0.25123516
KAT2B--23529
GBA--123666
WWTR1--24317
CDK5RAP1--24649
TARBP2--24667
DUSP22--24825
FGFR1OP--24857
SMPD1--125116
AIDA--25211
CHORDC1--25294
CAV1--125381
SFN--25459
DNAJA3--25610
PLK1--25783

Network

GO:0006469

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
GNAQguanine nucleotide binding protein (G protein), q polypeptide Entrez:2776  HGNC: 4390  HPRD: 02998 
APCadenomatous polyposis coli Entrez:324  HGNC: 583  HPRD: 01439  Ensembl: ENSG00000134982 
LRP6low density lipoprotein receptor-related protein 6 Entrez:4040  Ensembl: ENSG00000070018  HGNC: 6698  HPRD: 04617 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
GNAQguanine nucleotide binding protein (G protein), q polypeptide
APCadenomatous polyposis coli
LRP6low density lipoprotein receptor-related protein 6
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
GNAQGNAQguanine nucleotide binding protein (G protein), q polypeptide
APCAPCadenomatous polyposis coli
LRP6LRP6low density lipoprotein receptor-related protein 6

Troyanskaya Laboratory - Princeton University