ASD

GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway (37)

GeneInput weightStandardRank
HGS--152
AP2S1--210
ARHGEF7--215
SH3GL2--454
AP2M1--779
CDC42--1138
SPRY2--1454
CBL--1478
CLTA--1495
CLTC--1904
EPS15L1--2046
AP2A2--2352
EGFR--12546
GRB2--2962
DAB2IP--3482
SH3KBP1--4166
AP2A1--4845
PTPRF--5040
EPS15--5197
ERRFI1--6649
UBC--6756
AP2B1--6850
STAM--7024
ZFYVE28--7781
NUP62--18755
PTPRJ--19136
SPRY1--10636
EGF0.25112881
PSEN1--18523
UBB--19448
EPN1--19827
ZGPAT--20366
CBLC--21497
SNX6--22713
STAM2--23860
RPS27A--24381
UBA52--24384

Network

GO:0042059

Network
Enrichment
NameDescriptionExternal IDs
HGShepatocyte growth factor-regulated tyrosine kinase substrate Entrez:9146  Ensembl: ENSG00000185359  HPRD: 05085  HGNC: 4897 
AP2S1adaptor-related protein complex 2, sigma 1 subunit Entrez:1175  HPRD: 03762  Ensembl: ENSG00000042753  HGNC: 565 
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 7 Entrez:8874  Ensembl: ENSG00000102606  HGNC: 15607  HPRD: 05688 
SH3GL2SH3-domain GRB2-like 2 Entrez:6456  HGNC: 10831  Ensembl: ENSG00000107295  HPRD: 05125 
AP2M1adaptor-related protein complex 2, mu 1 subunit Entrez:1173  Ensembl: ENSG00000161203  HPRD: 03014  HGNC: 564 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
HGShepatocyte growth factor-regulated tyrosine kinase substrate
AP2S1adaptor-related protein complex 2, sigma 1 subunit
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 7
SH3GL2SH3-domain GRB2-like 2
AP2M1adaptor-related protein complex 2, mu 1 subunit
Query geneGeneGene descriptionEdge score
HGSHGShepatocyte growth factor-regulated tyrosine kinase substrate
AP2S1AP2S1adaptor-related protein complex 2, sigma 1 subunit
ARHGEF7ARHGEF7Rho guanine nucleotide exchange factor (GEF) 7
SH3GL2SH3GL2SH3-domain GRB2-like 2
AP2M1AP2M1adaptor-related protein complex 2, mu 1 subunit

Troyanskaya Laboratory - Princeton University