ASD

GO:0051241 negative regulation of multicellular organismal process (269)

GeneInput weightStandardRank
ADNP1.0171
HTR2A0.251121
PIK3R10.251150
GRIK20.51232
GABBR10.251264
BMPR2--1281
SLC6A10.251313
SFRP1--387
GRIK1--481
UBE2D3--528
CRH--563
NPY5R0.251725
TAC10.251726
MGEA5--732
STXBP1--769
TGFB2--834
DRD10.251899
RAPGEF40.251904
ADORA1--960
SOX9--1970
PTCH1--1972
CALCA--1013
ADRB1--1057
DRD50.2511103
CX3CL1--1199
GRIK30.2511247
GNAI3--1262
GNAI1--1468
LEF1--1499
RAC1--1617
CHRNA70.511837
ADRA1A--1858
AGTR20.2511955
CARTPT0.2511957
GUCY1A3--1997
ACHE--2025
ATP1A2--12247
BCOR--12290
SLC24A2--2302
FKBP1B--2346
GFRA4--2425
GHSR0.2512467
BCL6--2550
ATG12--2598
SOD1--12702
BCHE--2809
TBX5--2836
NOTCH1--12865
CXADR--2887
ITCH--2932
GLRA1--2965
MYLIP--3008
HRG--3052
SMURF1--3060
PTK2B--3063
RBP4--3448
IL12B--3596
KLF4--3609
RARA0.2513695
HS3ST50.2513697
SERPINE2--3708
PDGFA--3731
DRD20.2513749
AVPR1A0.513803
TNR--3868
FGF23--13888
TSPO0.2514009
AKAP1--4078
VEGFA0.2514087
HSF1--4101
SLC6A40.2514137
GSK3A--4141
IRF3--4175
MSTN--4329
TNFAIP3--4469
STATH--4554
FURIN--4605
SOX8--4609
KAT5--4618
CYLD--14624
F11--14760
CD83--4926
PTGS20.2515085
RGS2--5095
BMP10--5102
DUSP10--5172
IFNB1--5250
ADAM17--5323
RAI1--5351
PRNP--15418
NOG--15439
OSR1--5691
TMPRSS6--15797
GNAI2--5860
CST3--15894
ATP1A10.2515927
ADRBK1--6028
ADIPOQ0.2516032
CIDEA--6211
NGFR0.2516212
PCBP2--6256
OXTR0.516388
BMP4--16499
PLN0.2516577
NDFIP1--6744
UBC--6756
KNG1--6802
CIITA--16875
SOST--6885
TWIST1--16980
AVPR2--17031
APLN--7041
TNFSF4--7262
LRPAP1--7302
CYBA--17322
IFNA2--7694
XCL1--7819
WNT11--7820
ADRA1D--7837
IL2--7838
P2RX7--7888
PIN1--7940
MC1R--17999
RNF125--8017
HTR1B0.2518092
CD24--18102
FRZB--8105
GSTP10.2518742
ARG2--8780
LRRK2--18802
ABCG8--9041
PLG--9166
GHRL0.2519242
IL10--19513
EDN1--9540
ABHD6--10063
IFNL1--10151
IL12A--10482
IL23R--110545
KRT1--110570
ARRB2--10647
TBK1--10660
GIMAP5--10690
PCSK9--10760
GATA6--110828
TRAF3--11036
ATG5--11069
IL23A--11134
TSPAN8--11163
OXT0.25111176
AHSG--11515
APOH--11562
HCRT0.25111633
CNR20.25111649
ASPN--11718
LEP0.25111864
SMTNL1--11942
THBD--11960
SCGB1A1--12372
FOXP3--112457
PMCH--12542
IL6--112695
TLR4--112795
IFNG--112827
KCNQ4--112849
IL13--12888
KLKB1--12910
TGFB3--113097
VTN--13271
AGT--113305
TLR9--13360
AVP--113439
TIGIT--13464
IL33--13620
UTS2R--13768
APOC2--13818
ABCG5--14086
MGLL--14193
IRAK3--14633
APOA2--14659
CMKLR1--14683
HDAC7--14702
TNNT1--14867
POMC0.25114990
OTUD5--15109
TNF0.25115243
TWIST2--15321
CAV3--115414
SERPINB2--15479
INHBA--16974
F2--118599
SERPINF2--18906
APOA1--118958
UBB--19448
ADORA2B--19522
NLRC5--19618
NDRG2--19677
NLRP12--19807
IL6R--19897
PROC--19898
ARRB1--19906
F2RL1--19969
TGFB10.25120135
APOC3--20262
TRIM25--20289
JAK3--20340
EIF2AK3--20456
NOS3--20542
LBP--20559
ANXA2--20584
BPI--20592
CHRFAM7A--20694
KLF2--20711
PLAUR--20792
HERC5--20857
TAX1BP1--20955
PLAU--20969
PDGFB--21071
ADM--21106
F12--121126
GRID2IP--21156
VSIG4--21323
SRGN--21336
TNFRSF11B--21340
CD380.25121442
NOD2--121514
BBS2--121914
IL20RB--22045
INS--122047
ATP2A1--122234
P2RX4--22325
ANXA5--22365
PLAT--22444
DDX58--22544
KLK8--22593
TNFRSF1A--22842
GP1BA--123019
ISG15--23058
IDO1--23074
ADRB20.25123251
MAVS--23348
APOE0.25123516
SLC11A1--23561
ANXA2P2--23661
GBA--123666
APOC1--23668
NCKAP1L--23771
INPP5D--23776
HMOX1--23938
P2RY2--24088
ANPEP--24320
RPS27A--24381
UBA52--24384
THBS1--24444
AXL--24522
RNF135--24538
IKBKE--24643
UBE2L6--24693
ADA0.5124751
ECM1--124768
NR1H3--25006
ACP5--25019
SERPINE10.25125055
NLRX1--25070
GLRX3--25135
UBA7--25152
IFIH1--25300
FXN--125604
ANXA4--25797

Network

GO:0051241

Network
Enrichment
NameDescriptionExternal IDs
ADNPactivity-dependent neuroprotector homeobox Entrez:23394  Ensembl: ENSG00000101126  HPRD: 09793  HGNC: 15766 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Entrez:5295  HGNC: 8979  Ensembl: ENSG00000145675  HPRD: 01381 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
GABBR1gamma-aminobutyric acid (GABA) B receptor, 1 Entrez:2550  HGNC: 4070  Ensembl: ENSG00000204681  HPRD: 04644 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
ADNPactivity-dependent neuroprotector homeobox
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
GRIK2glutamate receptor, ionotropic, kainate 2
GABBR1gamma-aminobutyric acid (GABA) B receptor, 1
Query geneGeneGene descriptionEdge score
ADNPADNPactivity-dependent neuroprotector homeobox
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
PIK3R1PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2
GABBR1GABBR1gamma-aminobutyric acid (GABA) B receptor, 1

Troyanskaya Laboratory - Princeton University