ASD

GO:0043410 positive regulation of MAPKKK cascade (127)

GeneInput weightStandardRank
PLCB1--148
FBXW7--198
SOX2--1200
PRKCE--204
FGFR2--1237
GRM50.251240
IGF1R--252
FGF9--262
MAPK8IP2--418
TGFB2--834
HIPK2--1051
CDC42--1138
GAB1--1198
SEMA4C--1304
TAOK1--1336
FZD7--1357
SPRY2--1454
MIF0.2511552
TAOK20.2511633
DCC--1687
ESR10.2511791
ADRA1A--1858
AR0.2511902
MID1--2259
WWC1--2513
FGFR3--12640
ADRB3--12953
MAP3K10--2968
PELI2--3014
WNT5A--3319
TAOK3--3466
CDON--3487
BMPER--3497
PDGFA--3731
DRD20.2513749
NOX4--3804
EDNRA--13857
FGF23--13888
ITGB1--3903
KL--3938
WNT16--4117
LPAR1--4170
ANGPT1--4182
FGF20--4263
AXIN1--14419
FGF10--14532
TRAF4--4556
IL1A--4651
FGF4--4938
EDA2R--4972
HRAS0.2515086
GCG--5190
TNFSF11--15271
TNFRSF11A--15293
TEK--5322
RYK--5383
INSR--15872
DUSP19--6060
FGF18--6382
LPAR2--6450
BMP4--16499
WNT7B--7113
FGF21--7209
TAB1--7218
ILK--7305
WNT7A--7312
GRM4--7321
IL11--7718
GADD45B--8312
GPR55--8693
CTNNB10.519066
GPER1--9912
ARRB2--10647
IL1B--110818
BRAF--111149
IL26--11645
LEP0.25111864
LPAR3--11897
ARHGAP8--11916
VEGFB--11980
FGF19--12130
SORBS3--12437
IL6--112695
MAP3K11--12938
GADD45G--13071
FGF2--13150
AGT--113305
TLR9--13360
SEMA7A--13700
CCL19--14578
TNF0.25115243
OSM--19580
IL6R--19897
ARRB1--19906
SDCBP--19967
F2RL1--19969
F2R--20036
MAP4K2--20522
TIRAP--20658
CD44--20701
RIPK2--20830
PDGFB--21071
TRAF7--21319
NOD2--121514
CCL21--21829
INS--122047
S100A7--22068
LAMTOR1--22090
LIF--22134
MAP4K1--22336
CCR7--22367
IGF20.25122401
TLR3--22478
TPD52L1--22519
NENF--22557
CD27--22836
ST5--22969
MYD88--23106
ERBB2--123130
PDGFRB--23242
ADRB20.25123251
NOD1--23388
CARD9--123577
CD36--23662
CD74--24030
DUSP22--24825
GAS6--25481

Network

GO:0043410

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Entrez:55294  HPRD: 05888  Ensembl: ENSG00000109670  HGNC: 16712 
SOX2SRY (sex determining region Y)-box 2 Entrez:6657  HGNC: 11195  HPRD: 08921  Ensembl: ENSG00000181449 
PRKCEprotein kinase C, epsilon Entrez:5581  HPRD: 01500  HGNC: 9401  Ensembl: ENSG00000171132 
FGFR2fibroblast growth factor receptor 2 Entrez:2263  HPRD: 01492  Ensembl: ENSG00000066468  HGNC: 3689 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
SOX2SRY (sex determining region Y)-box 2
PRKCEprotein kinase C, epsilon
FGFR2fibroblast growth factor receptor 2
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
FBXW7FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
SOX2SOX2SRY (sex determining region Y)-box 2
PRKCEPRKCEprotein kinase C, epsilon
FGFR2FGFR2fibroblast growth factor receptor 2

Troyanskaya Laboratory - Princeton University