ASD

GO:0051058 negative regulation of small GTPase mediated signal transduction (27)

GeneInput weightStandardRank
NF10.251372
DGKZ--547
SLIT2--659
CUL31.011093
DLC1--1282
SPRY2--1454
ADRA1A--1858
RASAL2--1889
RASA1--1983
TNFAIP1--2123
STMN3--2468
BCL6--2550
PPP2CB--2931
KCTD130.2513132
DAB2IP--3482
RASAL1--3614
SYNGAP11.014039
ARAP3--4767
RASA2--4877
NUP62--18755
RASA4--8961
SPRY1--10636
TNK1--10857
SCAI--11212
MFN2--111607
RASA3--15787
RASAL3--19660

Network

GO:0051058

Network
Enrichment
NameDescriptionExternal IDs
NF1neurofibromin 1 Entrez:4763  HGNC: 7765  HPRD: 01203  Ensembl: ENSG00000196712 
DGKZdiacylglycerol kinase, zeta Entrez:8525  HPRD: 03260  HGNC: 2857  Ensembl: ENSG00000149091 
SLIT2slit homolog 2 (Drosophila) Entrez:9353  Ensembl: ENSG00000145147  HPRD: 04776  HGNC: 11086 
CUL3cullin 3 Entrez:8452  HPRD: 09123  HGNC: 2553  Ensembl: ENSG00000036257 
DLC1deleted in liver cancer 1 Entrez:10395  HPRD: 05035  HGNC: 2897  Ensembl: ENSG00000164741 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
NF1neurofibromin 1
DGKZdiacylglycerol kinase, zeta
SLIT2slit homolog 2 (Drosophila)
CUL3cullin 3
DLC1deleted in liver cancer 1
Query geneGeneGene descriptionEdge score
NF1NF1neurofibromin 1
DGKZDGKZdiacylglycerol kinase, zeta
SLIT2SLIT2slit homolog 2 (Drosophila)
CUL3CUL3cullin 3
DLC1DLC1deleted in liver cancer 1

Troyanskaya Laboratory - Princeton University