ASD

GO:0046676 negative regulation of insulin secretion (23)

GeneInput weightStandardRank
PPP3CA--244
PDE8B--1287
SFRP1--387
ABCC8--1406
IRS1--11374
ADRA2A0.2511399
PFKL--2192
GHSR0.2512467
INHBB--2842
PDE4C--3021
DRD20.2513749
PDE3B--3819
ACVR1C--3963
SIRT4--4652
KCNQ1--17724
SYTL4--7863
KCNJ11--19151
GHRL0.2519242
REST--9779
PSMD9--13911
SREBF1--19464
FAM3D--20640
HADH--125329

Network

GO:0046676

Network
Enrichment
NameDescriptionExternal IDs
PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme Entrez:5530  HGNC: 9314  HPRD: 00234  Ensembl: ENSG00000138814 
PDE8Bphosphodiesterase 8B Entrez:8622  HGNC: 8794  Ensembl: ENSG00000113231  HPRD: 04546 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Entrez:6833  Ensembl: ENSG00000006071  HPRD: 02741  HGNC: 59 
IRS1insulin receptor substrate 1 Entrez:3667  HPRD: 00943  HGNC: 6125 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme
PDE8Bphosphodiesterase 8B
SFRP1secreted frizzled-related protein 1
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8
IRS1insulin receptor substrate 1
Query geneGeneGene descriptionEdge score
PPP3CAPPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme
PDE8BPDE8Bphosphodiesterase 8B
SFRP1SFRP1secreted frizzled-related protein 1
ABCC8ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8
IRS1IRS1insulin receptor substrate 1

Troyanskaya Laboratory - Princeton University