ASD

GO:0010498 proteasomal protein catabolic process (160)

GeneInput weightStandardRank
PSMA1--58
PSMD14--104
PSMA4--166
FBXW7--198
SIAH1--223
PSMB3--234
PSMA5--284
PSMD8--371
PSMA3--460
CUL1--478
PSMB1--501
UBE2D3--528
PPP2R5C--555
TBL1XR10.251581
PSMC6--679
PSMD6--688
PSMB7--745
TRIM9--757
PSME4--787
PSMC2--815
FBXW11--859
TOPORS--1894
PSMD11--967
RNF4--973
RBX1--1044
PSMB4--1091
CUL31.011093
PSMD1--1168
PSMA7--1174
TBL1X0.2511228
PSMC4--1269
PSMC1--1296
PSMA6--1510
PSMD12--1573
UBE2I--1578
CDC34--1592
PSMB6--1607
PSMD2--1706
BUB3--1718
BTRC--1884
PSMC5--1897
PSMD3--2008
UBE2S--2043
PSMD4--2087
TNFAIP1--2123
RNF103--2156
PSMC3--2240
PSMD10--2412
PSMD7--2481
YOD1--2571
PSMA2--2699
FZR1--2920
PPP2CB--2931
PSMD13--3051
SMURF1--3060
KCTD130.2513132
TRIM13--3602
FBXL3--3648
WWP1--3744
UBE2B--4057
CRBN--4203
STUB1--4250
SEC61B--4578
KLHL20--4811
C2orf40--5001
ANAPC2--5008
TMEM67--15217
SKP1--5249
KIAA0368--5305
DNAJB2--6026
PCBP2--6256
FOXRED2--6748
UBC--6756
RNF5--7182
PMAIP1--7385
VCP--7434
UBE2E1--7950
NPLOC4--9152
PCNP--9220
BIRC2--9515
CDC27--9665
PSMA8--10087
ARRB2--10647
FBXO45--10684
WWP2--11885
PSMB2--11986
RAD23A--11998
FBXL15--12126
PSMB11--12480
WFS10.25112793
NHLRC1--113198
PSMD9--13911
PSME2--14327
CDC23--14728
ANAPC11--14928
RNF216--17136
FBXO31--17598
FBXO2--18983
HSPA5--19143
DDB1--19185
UBB--19448
OS9--19622
PSMD5--19823
ARRB1--19906
DERL3--20109
KCTD10--20198
FBXO4--20319
USP19--20335
RNF187--20424
ERCC8--120608
DERL2--20749
AMFR--20817
PSME1--21072
SYVN1--21151
ANAPC10--21179
PSMB9--21373
HSP90B1--21432
PSMB10--21853
DERL1--22108
PSMB8--22146
PSME3--22162
CDC26--22265
EDEM1--22357
PSMF1--22424
RBCK1--22556
EDEM3--22871
FBXL5--22878
FAF1--23304
ERLEC1--23306
JKAMP--23394
HECTD3--23477
FBXO6--23542
UBXN1--23735
DNAJB9--24370
RPS27A--24381
UBA52--24384
ANAPC4--24419
ANAPC7--24632
UBE2D1--24988
CDC16--24989
CDK1--25053
CCNB1--25174
ANAPC1--25203
PSMB5--25250
ERLIN1--25276
MAD2L1--25321
PTTG1--25330
ANAPC5--25367
CDK2--25445
FBXO5--25488
ERLIN2--25501
AURKB--25545
CCNF--25571
SKP2--25574
CDC20--25608
UBE2C--25614
DNAJC10--25717
BUB1B--125766
AURKA--125772
PLK1--25783

Network

GO:0010498

Network
Enrichment
NameDescriptionExternal IDs
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1 Entrez:5682  Ensembl: ENSG00000129084  HPRD: 04170  HGNC: 9530 
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 Entrez:5685  Ensembl: ENSG00000041357  HPRD: 10168  HGNC: 9533 
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Entrez:55294  HPRD: 05888  Ensembl: ENSG00000109670  HGNC: 16712 
SIAH1siah E3 ubiquitin protein ligase 1 Entrez:6477  Ensembl: ENSG00000196470  HGNC: 10857  HPRD: 03736 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
SIAH1siah E3 ubiquitin protein ligase 1
Query geneGeneGene descriptionEdge score
PSMA1PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMA4PSMA4proteasome (prosome, macropain) subunit, alpha type, 4
FBXW7FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
SIAH1SIAH1siah E3 ubiquitin protein ligase 1

Troyanskaya Laboratory - Princeton University