ASD

GO:0006140 regulation of nucleotide metabolic process (349)

GeneInput weightStandardRank
GNAO1--4
GABBR20.25142
PLCB1--148
NTRK20.25151
ADNP1.0171
PAFAH1B10.25174
RGS70.251135
GRM70.251137
ABR--160
AMPH--169
ADCY2--175
RGS4--178
GNAQ--189
RABGAP1--212
DNAJB6--222
ADCYAP1--230
SSTR2--251
GABBR10.251264
RASGRF1--335
NF10.251372
SFRP1--387
PGAM1--399
PTPRN20.251405
GSK3B--427
ARHGAP5--464
ADCY10.251466
JUN--511
RAPGEF2--540
CRHR1--589
APLP1--591
GRM3--652
SIPA1L1--716
AGAP10.251766
TSC10.251790
RGS6--805
SOS1--1810
RABGAP1L--846
GNAZ--856
RGS11--884
DRD10.251899
MAP2K10.251907
ARHGAP35--908
ADORA1--960
OPRK10.251996
CALCA--1013
NPY2R0.2511024
ADRB1--1057
NDEL10.2511074
DRD50.2511103
DGKI--1124
GNAL--1177
FGD1--11182
NPY1R0.2511190
GRIK30.2511247
GUCA1A--11258
GNAI3--1262
ADCYAP1R1--1273
DLC1--1282
FSHR--11398
ADRA2A0.2511399
GRM80.2511404
RALGAPA1--1420
SPRY2--1454
GNAI1--1468
PALM--1501
CAP2--1512
RAP1GAP--1556
THY1--1580
ASAP2--1637
RGS17--1702
GRM2--1757
AKAP5--1759
DOCK40.2511765
VIPR2--1823
BCR--11839
GNAS--11842
ADCY9--1850
ARFGAP1--1852
RASAL2--1889
SPECC1L--1912
TBC1D10B--1952
RASA1--1983
PTHLH--11993
GUCY1A3--1997
EDNRB--12042
ELMOD1--2135
RAP1GDS1--2341
CHN2--2347
HTR70.2512365
AGAP2--2378
CALCR--2381
STMN3--2468
GIT1--2489
CAP1--2541
BCL6--2550
DOCK1--2675
RAPGEF6--2744
PREX1--2760
ADCY8--2785
RGS5--2795
ADCY6--2877
MCHR10.2512905
VAV3--2908
ADRB3--12953
FZD10--2957
LHCGR0.2513057
PTK2B--3063
ASAP1--3096
ALDOB--3137
PREX2--3163
SMAP1--3243
ARHGAP1--3304
HTR1A0.2513315
WNT5A--3319
TSHR--3382
DAB2IP--3482
AGAP3--3546
ARAP2--3583
CDKL5--13600
AHSA1--3607
RASAL1--3614
ARHGAP26--13662
CHRM50.2513694
DRD20.2513749
RXFP1--3767
MC2R--3795
GNG7--3815
AKAP12--3839
MC4R0.2513850
EDNRA--13857
RGS12--3946
SYNGAP11.014039
GSK3A--4141
HTR4--4168
GHRHR--4237
PXK--4240
AXIN2--14260
FLNA--14285
RGS20--4292
ADCY5--4295
S1PR1--4301
P2RY1--4342
DRD30.2514349
CALCRL0.2514392
AXIN1--14419
AGAP7--4521
FGF10--14532
ARHGAP29--4559
RGS16--4657
ABCA1--14703
ARAP3--4767
RALGAPA2--4803
AGAP4--4843
AIPL1--14858
RASA2--4877
ACAP3--4921
DYNLT1--4976
MC5R--4977
MYO9B0.515005
CBS0.2515018
MLST8--5028
RGS2--5095
RGS8--5148
GCG--5190
MRAP2--5265
GPR3--5301
RANGAP1--5328
RGS9--5332
NPR3--5370
ARHGAP6--5374
CHRM4--5408
TBCD--5702
ADCY3--5755
SNX18--5776
GNAI2--5860
BVES--5886
RXFP2--15887
GALR1--5908
ARL2--5930
ACR--6002
OPRD10.2516030
BIN1--6197
OPRL10.2516271
RHOG--6279
ALS2--16326
RGS22--6455
ADAP1--6573
OPHN10.516584
RALBP1--6643
ERRFI1--6649
ALS2CR12--6669
GNA13--6683
ADORA3--6739
TNNT2--16745
S1PR3--6774
GCGR--16828
RGS13--6883
PTH--6947
HTR2B--6992
DRD40.2517021
AVPR2--17031
ARHGEF10--7111
CASR--7200
GRM4--7321
GRHL3--7409
FGD4--17457
GHRH--7478
SYDE2--7604
FOXJ1--7628
MYBPC3--17697
WNT11--7820
PIN1--7940
MC1R--17999
HTR1B0.2518092
AGFG1--8117
CXCL13--8148
MC3R0.2518188
GPR26--8197
AGAP8--8245
RASGRP3--8406
ADORA2A0.2518408
NTRK10.2518522
FGD3--8790
LRRK2--18802
RASA4--8961
ADCY4--9091
AGAP5--9202
AGAP11--9307
RGN--9311
RGS18--9348
NPPC--9349
TSC20.2519351
RAB3GAP1--9492
EDN1--9540
CCL11--9615
SYDE1--9690
GLP1R--9893
GUCA2B--10165
TBC1D15--10227
GIPR--10369
RAB3GAP2--10501
RGS1--10535
FGD5--10619
SPRY1--10636
UCN3--10665
AGAP9--10698
MRAP--10905
PTGDR2--10914
PDZD3--11066
SNX9--11169
ARHGAP8--11916
ASAP3--11995
FGD6--12199
IQGAP1--12240
GUCA1B--12297
CORT--12689
TNNI3--112758
RGS14--12999
AVP--113439
FICD--13795
MYH6--113823
RGS21--13909
SMAP2--14426
ARHGEF19--14560
CCL19--14578
SSTR50.25114876
GALR2--14926
LTB4R2--15126
ADM2--15255
TAX1BP3--15553
GALR3--15691
RASA3--15787
SNX13--15948
AGAP10--16012
FZD2--16930
CTGLF11P--17728
ARHGEF10L--17881
AJUBA--18146
ARFGAP2--18897
INSL3--119059
ARHGEF6--19241
AGAP6--19286
EPHA2--119467
ALDH1A1--19488
CDC42EP2--19500
ADORA2B--19522
DOCK7--19597
RASAL3--19660
ARRB1--19906
FGD2--20103
ACAP2--20167
PTPLAD1--20272
BNIP2--20381
MYL3--120524
NOS3--20542
RGS19--20558
P2RY11--20669
OXER1--20906
GPR78--20984
ARHGAP15--21045
AGFG2--21063
MTOR--21095
ARHGEF16--21200
SIPA1--21260
ARHGAP4--21362
GABARAPL2--21370
ELMOD2--21506
PDE6D--21624
CCL21--21829
CCL24--21868
SLC9A3R1--21898
RALGAPB--22093
S1PR4--22105
RP2--122116
GMIP--22274
CCR7--22367
ARHGAP9--22481
GPR65--22555
ATPIF1--22561
GIT2--22751
CCL26--22814
ADAP2--22843
ADRB20.25123251
GNB2L1--23282
CCR2--23296
RGS3--23349
APOE0.25123516
SCRIB--23676
TBC1D2--23738
NCKAP1L--23771
TNNC1--123782
VAV1--23876
TIMP2--23892
ARHGAP27--23975
TNNT3--124213
TPM1--124247
DNAJC1--24415
CDA--24491
RGS10--24612
ARAP1--24899
RACGAP1--24932
NPR1--24948
ACAP1--25044
ADCY7--25408
TPM2--125414
ARFGAP3--25472
MYL4--25690
OXA1L--25710
DNAJC10--25717

Network

GO:0006140

Network
Enrichment
NameDescriptionExternal IDs
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Entrez:2775  HPRD: 00757  HGNC: 4389  Ensembl: ENSG00000087258 
GABBR2gamma-aminobutyric acid (GABA) B receptor, 2 Entrez:9568  Ensembl: ENSG00000136928  HGNC: 4507  HPRD: 09552 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
NTRK2neurotrophic tyrosine kinase, receptor, type 2 Entrez:4915  Ensembl: ENSG00000148053  HPRD: 02712  HGNC: 8032 
ADNPactivity-dependent neuroprotector homeobox Entrez:23394  Ensembl: ENSG00000101126  HPRD: 09793  HGNC: 15766 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GABBR2gamma-aminobutyric acid (GABA) B receptor, 2
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
NTRK2neurotrophic tyrosine kinase, receptor, type 2
ADNPactivity-dependent neuroprotector homeobox
Query geneGeneGene descriptionEdge score
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GABBR2GABBR2gamma-aminobutyric acid (GABA) B receptor, 2
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
NTRK2NTRK2neurotrophic tyrosine kinase, receptor, type 2
ADNPADNPactivity-dependent neuroprotector homeobox

Troyanskaya Laboratory - Princeton University