ASD

GO:0043087 regulation of GTPase activity (191)

GeneInput weightStandardRank
GNAO1--4
PLCB1--148
PAFAH1B10.25174
RGS70.251135
ABR--160
AMPH--169
RGS4--178
GNAQ--189
RABGAP1--212
RASGRF1--335
NF10.251372
SFRP1--387
PTPRN20.251405
GSK3B--427
ARHGAP5--464
JUN--511
RAPGEF2--540
SIPA1L1--716
AGAP10.251766
TSC10.251790
RGS6--805
SOS1--1810
RABGAP1L--846
RGS11--884
MAP2K10.251907
ARHGAP35--908
NDEL10.2511074
DGKI--1124
FGD1--11182
DLC1--1282
RALGAPA1--1420
SPRY2--1454
RAP1GAP--1556
THY1--1580
ASAP2--1637
RGS17--1702
DOCK40.2511765
BCR--11839
ARFGAP1--1852
RASAL2--1889
TBC1D10B--1952
RASA1--1983
ELMOD1--2135
RAP1GDS1--2341
CHN2--2347
AGAP2--2378
STMN3--2468
GIT1--2489
BCL6--2550
DOCK1--2675
RAPGEF6--2744
PREX1--2760
RGS5--2795
VAV3--2908
FZD10--2957
PTK2B--3063
ASAP1--3096
PREX2--3163
SMAP1--3243
ARHGAP1--3304
DAB2IP--3482
AGAP3--3546
ARAP2--3583
CDKL5--13600
RASAL1--3614
ARHGAP26--13662
RGS12--3946
SYNGAP11.014039
AXIN2--14260
RGS20--4292
S1PR1--4301
AXIN1--14419
AGAP7--4521
ARHGAP29--4559
RGS16--4657
ARAP3--4767
RALGAPA2--4803
AGAP4--4843
RASA2--4877
ACAP3--4921
DYNLT1--4976
MYO9B0.515005
MLST8--5028
RGS2--5095
RGS8--5148
RANGAP1--5328
RGS9--5332
ARHGAP6--5374
TBCD--5702
SNX18--5776
BVES--5886
ARL2--5930
BIN1--6197
RHOG--6279
ALS2--16326
RGS22--6455
ADAP1--6573
OPHN10.516584
RALBP1--6643
ERRFI1--6649
ALS2CR12--6669
RGS13--6883
HTR2B--6992
GRHL3--7409
FGD4--17457
SYDE2--7604
FOXJ1--7628
WNT11--7820
PIN1--7940
AGFG1--8117
CXCL13--8148
AGAP8--8245
RASGRP3--8406
FGD3--8790
LRRK2--18802
RASA4--8961
AGAP5--9202
AGAP11--9307
RGS18--9348
TSC20.2519351
RAB3GAP1--9492
CCL11--9615
SYDE1--9690
TBC1D15--10227
RAB3GAP2--10501
RGS1--10535
FGD5--10619
SPRY1--10636
AGAP9--10698
SNX9--11169
ARHGAP8--11916
ASAP3--11995
FGD6--12199
IQGAP1--12240
RGS14--12999
FICD--13795
RGS21--13909
SMAP2--14426
ARHGEF19--14560
CCL19--14578
TAX1BP3--15553
RASA3--15787
SNX13--15948
AGAP10--16012
CTGLF11P--17728
ARHGEF10L--17881
AJUBA--18146
ARFGAP2--18897
ARHGEF6--19241
AGAP6--19286
EPHA2--119467
ALDH1A1--19488
CDC42EP2--19500
DOCK7--19597
RASAL3--19660
ARRB1--19906
FGD2--20103
ACAP2--20167
PTPLAD1--20272
BNIP2--20381
RGS19--20558
ARHGAP15--21045
AGFG2--21063
MTOR--21095
ARHGEF16--21200
SIPA1--21260
ARHGAP4--21362
ELMOD2--21506
CCL21--21829
CCL24--21868
RALGAPB--22093
RP2--122116
GMIP--22274
CCR7--22367
ARHGAP9--22481
GPR65--22555
GIT2--22751
CCL26--22814
ADAP2--22843
GNB2L1--23282
RGS3--23349
SCRIB--23676
TBC1D2--23738
NCKAP1L--23771
VAV1--23876
ARHGAP27--23975
RGS10--24612
ARAP1--24899
RACGAP1--24932
ACAP1--25044
ARFGAP3--25472

Network

GO:0043087

Network
Enrichment
NameDescriptionExternal IDs
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Entrez:2775  HPRD: 00757  HGNC: 4389  Ensembl: ENSG00000087258 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Entrez:5048  HGNC: 8574  HPRD: 03329  Ensembl: ENSG00000007168 
RGS7regulator of G-protein signaling 7 Entrez:6000  HGNC: 10003  HPRD: 03948  Ensembl: ENSG00000182901 
ABRactive BCR-related Entrez:29  HGNC: 81  HPRD: 02649  Ensembl: ENSG00000159842 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
RGS7regulator of G-protein signaling 7
ABRactive BCR-related
Query geneGeneGene descriptionEdge score
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
PAFAH1B1PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
RGS7RGS7regulator of G-protein signaling 7
ABRABRactive BCR-related

Troyanskaya Laboratory - Princeton University