ASD

GO:0035023 regulation of Rho protein signal transduction (139)

GeneInput weightStandardRank
KALRN--56
PAFAH1B10.25174
TRIO0.51111
ABR--160
CDH2--164
ARHGEF7--215
ARHGEF4--265
TIAM1--325
RASGRF1--335
SFRP1--387
ARHGEF12--1393
GSK3B--427
ARHGAP5--464
JUN--511
ARHGEF11--705
TSC10.251790
SOS1--1810
ARHGEF9--1875
MCF2--892
ARHGAP35--908
FARP1--1023
MCF2L--1059
NDEL10.2511074
CUL31.011093
SOS2--1181
FGD1--11182
DLC1--1282
THY1--1580
RAC1--1617
AKAP13--1679
DOCK40.2511765
ITSN1--1789
ARHGEF2--1819
BCR--11839
ADRA1A--1858
ITSN2--1958
TNFAIP1--2123
RASGRF2--2414
STMN3--2468
BCL6--2550
PREX1--2760
VAV2--2850
VAV3--2908
FZD10--2957
PTK2B--3063
TIAM2--3070
KCTD130.2513132
PREX2--3163
ARHGEF17--3189
PLEKHG3--3279
ARHGAP1--3304
CDKL5--13600
ARHGAP26--13662
ARHGEF3--4159
LPAR1--4170
ARHGEF18--4257
ARHGEF38--4536
ARHGAP29--4559
ARAP3--4767
DYNLT1--4976
MYO9B0.515005
MLST8--5028
ARHGEF40--5081
ARHGAP6--5374
ARHGEF26--5440
BVES--5886
FARP2--5987
RHOG--6279
ALS2--16326
LPAR2--6450
OPHN10.516584
RALBP1--6643
ERRFI1--6649
MCF2L2--7037
DNMBP--7085
ARHGEF10--7111
GRHL3--7409
FGD4--17457
NET1--7500
SYDE2--7604
FOXJ1--7628
ABRA--7831
PIN1--7940
ARHGEF25--8032
GPR55--8693
FGD3--8790
NGEF--9344
SPATA13--9353
CCL11--9615
SYDE1--9690
PLEKHG2--10476
FGD5--10619
PLEKHG5--10686
PLEKHG4B--10742
SCAI--11212
ARHGEF33--11866
ARHGAP8--11916
FGD6--12199
ECT2L--12438
PLEKHG7--13086
FICD--13795
ARHGEF39--14085
ARHGEF19--14560
CCL19--14578
ARHGEF15--15322
TAX1BP3--15553
ARHGEF10L--17881
ARHGEF6--19241
EPHA2--119467
CDC42EP2--19500
DOCK7--19597
ARRB1--19906
F2RL1--19969
F2R--20036
FGD2--20103
OBSCN--20605
ARHGEF37--20661
ARHGAP15--21045
MTOR--21095
PLEKHG1--21120
ARHGEF16--21200
ARHGEF1--21297
ARHGAP4--21362
CCL21--21829
CCL24--21868
PLEKHG4--22016
GMIP--22274
CCR7--22367
GPR65--22555
ARHGEF5--22680
CCL26--22814
PLEKHG6--23259
SCRIB--23676
NCKAP1L--23771
VAV1--23876
ARHGAP27--23975
ECT2--24758
ARAP1--24899
ALS2CL--25765

Network

GO:0035023

Network
Enrichment
NameDescriptionExternal IDs
KALRNkalirin, RhoGEF kinase Entrez:8997  HPRD: 06859  HGNC: 4814  Ensembl: ENSG00000160145 
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Entrez:5048  HGNC: 8574  HPRD: 03329  Ensembl: ENSG00000007168 
TRIOtrio Rho guanine nucleotide exchange factor Entrez:7204  Ensembl: ENSG00000038382  HPRD: 03537  HGNC: 12303 
ABRactive BCR-related Entrez:29  HGNC: 81  HPRD: 02649  Ensembl: ENSG00000159842 
CDH2cadherin 2, type 1, N-cadherin (neuronal) Entrez:1000  Ensembl: ENSG00000170558  HGNC: 1759  HPRD: 00226 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
KALRNkalirin, RhoGEF kinase
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
TRIOtrio Rho guanine nucleotide exchange factor
ABRactive BCR-related
CDH2cadherin 2, type 1, N-cadherin (neuronal)
Query geneGeneGene descriptionEdge score
KALRNKALRNkalirin, RhoGEF kinase
PAFAH1B1PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
TRIOTRIOtrio Rho guanine nucleotide exchange factor
ABRABRactive BCR-related
CDH2CDH2cadherin 2, type 1, N-cadherin (neuronal)

Troyanskaya Laboratory - Princeton University