ASD

GO:0008277 regulation of G-protein coupled receptor protein signaling pathway (72)

GeneInput weightStandardRank
PLCB1--148
CAMK2B0.25155
RGS70.251135
RGS4--178
ADCYAP1--230
GRM50.251240
GNG4--457
USP33--542
SNCA--1667
CNTN2--674
RGS6--805
RGS11--884
ADRA2A0.2511399
PALM--1501
MGRN1--2277
GIT1--2489
TMOD2--2615
RGS5--2795
RIC8B--3558
DRD20.2513749
GNG7--3815
ITGB1--3903
RGS12--3946
PDE6H--4126
GSK3A--4141
RGS20--4292
DRD30.2514349
GRK5--4595
GRK4--4632
RGS16--4657
DYNLT1--4976
USP20--4986
RGS2--5095
RGS9--5332
GPSM1--6012
ADRBK1--6028
RAMP3--6821
RGS13--6883
PLCE1--6929
HTR2B--6992
HTR1B0.2518092
RPH3AL--8235
RASGRP4--8409
LRRK2--18802
RGS18--9348
EDN1--9540
RAMP2--9811
ABHD6--10063
GIPR--10369
ARRB2--10647
KLK6--10748
PTGDR2--10914
DTNBP1--11492
RGS14--12999
GRK1--113627
MGLL--14193
RAMP1--16109
KLK14--19554
ARRB1--19906
KLK5--20016
PDE6G--120364
ECE1--120540
GRK6--21376
RPGRIP1L--21472
GIT2--22751
PLD2--22908
ADRB20.25123251
RGS3--23349
PLEK--24240
ADA0.5124751
CAV2--25271
GTF2H2--25399

Network

GO:0008277

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta Entrez:816  Ensembl: ENSG00000058404  HGNC: 1461  HPRD: 12127 
RGS7regulator of G-protein signaling 7 Entrez:6000  HGNC: 10003  HPRD: 03948  Ensembl: ENSG00000182901 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary) Entrez:116  HGNC: 241  HPRD: 02369  Ensembl: ENSG00000141433 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta
RGS7regulator of G-protein signaling 7
RGS4regulator of G-protein signaling 4
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
CAMK2BCAMK2Bcalcium/calmodulin-dependent protein kinase II beta
RGS7RGS7regulator of G-protein signaling 7
RGS4RGS4regulator of G-protein signaling 4
ADCYAP1ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)

Troyanskaya Laboratory - Princeton University