ASD

GO:0032269 negative regulation of cellular protein metabolic process (252)

GeneInput weightStandardRank
PPP2CA--20
SET--31
PSMA1--58
PSMD14--104
YWHAB0.251107
PIK3R10.251150
PSMA4--166
PSMB3--234
SOX4--250
LRP6--279
PSMA5--284
PSMD8--371
SFRP1--387
FMR10.251434
PSMA3--460
AGO2--490
PSMB1--501
JUN--511
SLIT2--659
SNCA--1667
PSMC6--679
PSMD6--688
MGEA5--732
PSMB7--745
CTBP1--760
TSC10.251790
PSMC2--815
SMAD3--823
JARID2--946
PARK20.251952
PSMD11--967
PRKCZ--991
YWHAE--995
PSMB4--1091
PPP2R1A--1163
PSMD1--1168
PSMA7--1174
SMAD7--1192
BAG5--1229
PSMC4--1269
PSMC1--1296
BAG6--1305
PTEN1.011389
PRKCG--11483
PSMA6--1510
PSMD12--1573
PSMB6--1607
PSMD2--1706
BUB3--1718
N4BP1--1749
TNRC6A--1752
PSMC5--1897
PSMD3--2008
MASP1--2021
EDNRB--12042
PSMD4--2087
AGO3--2124
NDUFA13--12204
PSMC3--2240
BCOR--12290
SMAD6--2305
FXR1--2395
PSMD10--2412
CAPRIN1--2429
CIRBP--2440
DUSP6--2466
PSMD7--2481
TIA1--2578
PPP2R4--2609
PSMA2--2699
AGO1--2764
SKI--2904
FZR1--2920
PSMD13--3051
PAIP2--3171
CDK50.2513194
IGFBP5--3306
AGO4--3370
USP44--3406
INPP5J--3690
RARA0.2513695
SERPINE2--3708
SRP9--3762
HSP90AB1--3924
UBE2B--4057
RBM4--4069
AKAP1--4078
VPS28--4150
GLG1--4233
MAS1--4244
LIMK1--4265
CAPRIN2--4284
WNT1--4383
TNFAIP3--4469
WT1--14514
FURIN--4605
PTPN3--4627
SAMD4A--4734
MEN1--14917
ANAPC2--5008
PAX50.515041
SFRP2--5252
SERPINB10--5376
PRNP--15418
RASD2--5562
INSR--15872
NF2--15991
DNAJB2--6026
ADIPOQ0.2516032
ENPP1--16091
NR1H2--6183
IGF2BP1--6258
CLN8--16415
HHATL--6451
PRKCD--6504
ERRFI1--6649
UBC--6756
PAIP2B--6933
TWIST1--16980
PPEF2--7509
EIF4A3--7597
USP4--7808
IL2--7838
G6PD--7945
UBE2E1--7950
MET1.018002
YBX2--8277
TIMP1--8520
IL10--19513
EDN1--9540
IGF2BP2--19556
SOCS1--9583
CDC27--9665
GIPC1--9877
BDKRB2--10150
CLN3--110442
NANOS1--10456
TAF9--10627
PPAP2B--10628
ARRB2--10647
PRG3--10802
ATG5--11069
MLXIPL--11075
IGF2BP3--11232
TAF7--11434
DKK1--11567
IRF1--111641
ITGB30.5111817
PSMB2--11986
GCLC--12360
FOXP3--112457
DNMT1--13233
FAM129A--13686
MAD2L2--13802
PSMD9--13911
SPINK9--14309
PSME2--14327
ST13--14350
DNMT3B--14663
CDC23--14728
EIF4EBP2--14825
ANAPC11--14928
PEBP1--15772
HDAC6--16779
ST13P1--17709
BDKRB1--18217
PSEN1--18523
SHH--118571
F2--118599
DVL1P1--18731
ST13P4--18988
CNKSR3--19160
UBB--19448
PATL2--19573
NLRP12--19807
PSMD5--19823
ARRB1--19906
SAMSN1--19930
TGFB10.25120135
NFKB1--20281
EIF2AK3--20456
GRB7--20514
CDKN2A--120587
SERPINA5--20717
RAB23--20831
ACER2--20862
PSME1--21072
ANAPC10--21179
EIF2AK4--21300
PSMB9--21373
EIF4EBP3--21431
PSMB10--21853
INS--122047
PSMB8--22146
CALR--22152
PSME3--22162
CDC26--22265
APOA4--22292
IGFBP3--22342
PSMF1--22424
PLAT--22444
IBTK--22790
EIF4EBP1--22803
HNF4A--122965
PSEN2--23095
GNB2L1--23282
GTPBP4--23572
SRP14--23614
EIF2AK1--23647
UBXN1--23735
TIMP3--23921
APOM--24008
TINF2--24033
INPP5K--24055
A2M--24058
PTPN6--24184
WWTR1--24317
RPS27A--24381
UBA52--24384
DNAJC1--24415
ANAPC4--24419
EIF2B4--24428
IMPACT--24430
THBS1--24444
BRCA1--124573
ANAPC7--24632
ENG--124746
ANG--124879
TRIM21--24895
UBE2D1--24988
CDC16--24989
SERPINE10.25125055
SERPING1--125126
IGBP1--25127
EIF3E--25133
CCNB1--25174
ANAPC1--25203
PSMB5--25250
PML--25277
MAD2L1--25321
EIF2B5--25325
ANAPC5--25367
CAV1--125381
IDE--25443
EIF2B3--25449
ITGAV--25460
FBXO5--25488
CDC20--25608
UBE2C--25614
UFL1--25631
DNAJC10--25717
BUB1B--125766

Network

GO:0032269

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
SETSET nuclear oncogene Entrez:6418  HGNC: 10760  HPRD: 09023  Ensembl: ENSG00000119335 
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1 Entrez:5682  Ensembl: ENSG00000129084  HPRD: 04170  HGNC: 9530 
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
SETSET nuclear oncogene
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
SETSETSET nuclear oncogene
PSMA1PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Troyanskaya Laboratory - Princeton University