ASD

GO:0033674 positive regulation of kinase activity (325)

GeneInput weightStandardRank
PPP2CA--20
KRAS--157
GAP43--60
ADNP1.0171
YWHAB0.251107
HTR2A0.251121
ADCY2--175
FBXW7--198
GRM50.251240
MAP3K9--462
ADCY10.251466
DGKZ--547
SPAG9--558
PRKACB--584
CDK5R1--586
RELN1.01626
SNCA--1667
KIDINS220--701
MADD--759
CCND2--782
TAB2--785
TGFB2--834
MAP2K10.251907
GNG3--927
NRG10.251936
ADORA1--960
GRM10.251975
PROX1--997
CALCA--1013
AKT10.2511020
DGKI--1124
MAPK1--1128
CDC42--1138
GAB1--1198
MAP3K5--1220
MAP2K20.2511240
PRKAR1B--1257
CHRNA3--1266
PDCD10--1274
MAP3K7--1275
BAD--1290
DGKB--1341
ERBB3--1350
IRS1--11374
PRLR0.2511393
ADRA2A0.2511399
SPRY2--1454
TNIK--1531
EDN3--11577
RAC1--1617
TAOK20.2511633
ACVR2B--11676
SRCIN1--1738
PDPK1--1740
ZFP91--1788
CHRNA70.511837
PARD3--1845
ADCY9--1850
TGFA--1873
CCK0.2511899
SPECC1L--1912
CARTPT0.2511957
MAPK11--1962
PKN1--1967
DVL3--2090
DGKG--2155
PRKAR2B--2211
MAPK8IP3--2274
STK4--2276
PSMD10--2412
PRKAR1A--12428
EGFR--12546
MAPKBP1--2654
SOD1--12702
CRK--2713
ADCY8--2785
VAV2--2850
MAP3K13--2864
ADCY6--2877
MAP4K5--2894
VAV3--2908
FZD10--2957
MAP3K10--2968
PTK2B--3063
MAP3K2--3184
CDK50.2513194
RAF10.2513236
WNT5A--3319
MAP3K1--13381
DAB2IP--3482
CCDC88A--3536
TAB3--3641
DGKE--3651
MAP3K4--3663
PDGFA--3731
DRD20.2513749
NOX4--3804
DLG1--3822
EDNRA--13857
MAPKAPK2--3870
FLT10.2513953
MAPK14--3975
VEGFA0.2514087
PRKACG--4112
PDE6H--4126
LPAR1--4170
ANGPT1--4182
PRKAG2--14212
AXIN2--14260
PAK2--4270
ADCY5--4295
AXIN1--14419
FGF10--14532
TRAF4--4556
PROK2--14655
WNT3A--4747
DGKD--4786
PAK1--4940
HRAS0.2515086
SPHK2--5120
GCG--5190
CERK--5270
TNFRSF11A--15293
HGF0.2515313
ADAM17--5323
CXCR4--5414
PRDX2--5497
ADCY3--5755
MAP2K7--5837
GNAI2--5860
INSR--15872
ADIPOQ0.2516032
PLA2G1B--6059
DUSP19--6060
TDGF1--6132
NGF0.2516229
ALS2--16326
PFKFB2--6327
ZEB2--6361
STRADA--6362
MAPK30.2516426
LPAR2--6450
BMP4--16499
PDGFC--6530
CSF1--6542
DVL2--6546
DGKH--6642
UBC--6756
TNFSF15--6782
CHRM1--6796
PLCE1--6929
GCKR--6973
HTR2B--6992
DRD40.2517021
WNT7B--7113
FRS2--7173
TAB1--7218
TGFBR1--17268
ILK--7305
WNT7A--7312
GRM4--7321
FGD4--17457
PILRB--7462
JTB--7517
PRKD3--7603
IL2--7838
GH1--7858
RAPGEF1--7926
CCND1--17970
MET1.018002
HTR1B0.2518092
CD24--18102
GADD45B--8312
ADORA2A0.2518408
DAXX--8508
NTRK10.2518522
ADRA2C--8551
LAMTOR2--8770
LRRK2--18802
PROK1--9002
EREG--9052
ADCY4--9091
PIM1--9182
GHRL0.2519242
CD4--9401
KISS1R--9434
EDN1--9540
PRKACA--9630
DGKQ--9874
ERN1--9939
C1QTNF2--10034
SHC1--10045
GHR--110098
ADRA2B--10119
CDC25B--10174
PFKFB1--10385
TGFBR2--110407
AFAP1L2--10424
MAP2K6--10478
CCNY--10662
IL1B--110818
TLR6--10981
TRAF6--11055
BRAF--111149
PICK1--11315
PRKAR2A--11450
PIK3CB--11542
HCRT0.25111633
ITGB30.5111817
LPAR3--11897
DDR2--12143
CD81--112160
EPGN--12503
TLR4--112795
EGF0.25112881
MAP3K11--12938
GADD45G--13071
RAP1A--13091
TGFB3--113097
MS4A2--13136
FGF2--13150
AGT--113305
TLR9--13360
MDFI--13519
MALT1--13522
TNFRSF10B--13570
MAP2K3--13704
NRAS--114119
RPTOR--14284
CARD14--14340
CCL19--14578
ZP4--14747
CERKL--114754
IRAK2--15024
TNF0.25115243
ITGA1--15500
ELANE--115526
NBN--116066
DGKK--16992
ZP3--17443
AJUBA--18146
BDKRB1--18217
PSEN1--18523
EDN2--18677
TP73--18810
AZU1--18895
HSPA5--19143
IQGAP3--19438
UBB--19448
ADORA2B--19522
JAK2--119561
DOK7--19814
BIRC7--19826
HSPA2--20026
F2R--20036
TGFB10.25120135
PTPLAD1--20272
EPO--20282
PDE6G--120364
MAP4K2--20522
DUSP12--20763
RIPK2--20830
PDGFB--21071
SLC27A1--21124
CCND3--21136
STK3--21167
CLSPN--21302
TRAF7--21319
C5AR1--21363
FPR1--21375
AGK--21412
EFNA1--21477
NOD2--121514
PTPRC--21546
IRAK1--21640
MDFIC--21692
TNFRSF10A--21740
ADAM8--21797
CCL21--21829
C5--122004
INS--122047
LRP1--22276
MAP4K1--22336
CCR7--22367
IGF20.25122401
DBNL--22402
TLR3--22478
TPD52L1--22519
CYR61--22574
S1PR2--22592
RIPK1--22681
PRKAA1--22917
MUL1--22953
DGKA--23016
SDC4--23067
ERBB2--123130
PDGFRB--23242
ADRB20.25123251
NOD1--23388
STRADB--23510
IKBKG--123539
SLC11A1--23561
TRAF2--23686
AVPI1--23843
CARD10--23869
SYK--23906
CD74--24030
SPHK1--24069
MAPKAPK3--24170
MAP3K6--24220
RPS27A--24381
UBA52--24384
PRKAG1--24404
THBS1--24444
ANG--124879
ACSL1--24993
CDK1--25053
MRE11A--25110
ADAM9--125221
PPAP2A--25298
IL1RN0.25125385
ADCY7--25408
RAD50--25510
TPX2--25683
CENPE--25732

Network

GO:0033674

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
GAP43growth associated protein 43 Entrez:2596  Ensembl: ENSG00000172020  HPRD: 01198  HGNC: 4140 
ADNPactivity-dependent neuroprotector homeobox Entrez:23394  Ensembl: ENSG00000101126  HPRD: 09793  HGNC: 15766 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
KRASKirsten rat sarcoma viral oncogene homolog
GAP43growth associated protein 43
ADNPactivity-dependent neuroprotector homeobox
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
KRASKRASKirsten rat sarcoma viral oncogene homolog
GAP43GAP43growth associated protein 43
ADNPADNPactivity-dependent neuroprotector homeobox
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Troyanskaya Laboratory - Princeton University