ASD

GO:0046578 regulation of Ras protein signal transduction (243)

GeneInput weightStandardRank
PSD30.25140
KALRN--56
KRAS--157
PAFAH1B10.25174
TRIO0.51111
ABR--160
CDH2--164
ARHGEF7--215
ARHGEF4--265
TIAM1--325
RASGRF1--335
NF10.251372
SFRP1--387
ARHGEF12--1393
GSK3B--427
ARHGAP5--464
JUN--511
RAPGEF2--540
DGKZ--547
ARHGEF11--705
SIPA1L1--716
AGAP10.251766
TSC10.251790
SOS1--1810
RABGAP1L--846
ARHGEF9--1875
MCF2--892
MAP2K10.251907
ARHGAP35--908
SHOC2--982
FARP1--1023
MCF2L--1059
NDEL10.2511074
CUL31.011093
DGKI--1124
SOS2--1181
FGD1--11182
DLC1--1282
IQSEC3--1307
RALGAPA1--1420
SPRY2--1454
RAP1GAP--1556
THY1--1580
RAC1--1617
ASAP2--1637
AKAP13--1679
ARFGEF1--1707
DOCK40.2511765
IQSEC1--1775
ITSN1--1789
ARHGEF2--1819
BCR--11839
ARFGAP1--1852
ADRA1A--1858
PSD2--1863
RASAL2--1889
TBC1D10B--1952
ITSN2--1958
RASA1--1983
TNFAIP1--2123
PSD--2162
GBF1--2266
AGAP2--2378
RASGRF2--2414
STMN3--2468
GIT1--2489
BCL6--2550
CRK--2713
PREX1--2760
IGF10.2512793
VAV2--2850
VAV3--2908
PPP2CB--2931
FZD10--2957
CYTH2--3020
PTK2B--3063
TIAM2--3070
ASAP1--3096
KCTD130.2513132
PREX2--3163
ARHGEF17--3189
SMAP1--3243
PLEKHG3--3279
ARHGAP1--3304
ARF6--3317
KITLG--3334
DAB2IP--3482
AGAP3--3546
ARAP2--3583
CDKL5--13600
RASAL1--3614
ARHGAP26--13662
ARFGEF2--13666
SYNGAP11.014039
ARHGEF3--4159
LPAR1--4170
ARHGEF18--4257
S1PR1--4301
AGAP7--4521
FGF10--14532
ARHGEF38--4536
ARHGAP29--4559
SH2B2--4634
IQSEC2--4715
ARAP3--4767
RALGAPA2--4803
AGAP4--4843
RASA2--4877
ACAP3--4921
DYNLT1--4976
MYO9B0.515005
MLST8--5028
ARHGEF40--5081
HRAS0.2515086
RANGAP1--5328
ARHGAP6--5374
ARHGEF26--5440
CYTH1--5741
BVES--5886
FARP2--5987
ITPKB--6178
RHOG--6279
ALS2--16326
LPAR2--6450
CSF1--6542
ADAP1--6573
OPHN10.516584
RALBP1--6643
ERRFI1--6649
NOTCH2--16664
PLCE1--6929
HTR2B--6992
MCF2L2--7037
DNMBP--7085
ARHGEF10--7111
GRHL3--7409
FGD4--17457
NET1--7500
SYDE2--7604
FOXJ1--7628
WNT11--7820
ABRA--7831
PIN1--7940
ARHGEF25--8032
AGFG1--8117
CXCL13--8148
AGAP8--8245
RASGRP3--8406
RASGRP4--8409
GPR55--8693
NUP62--18755
FGD3--8790
RASA4--8961
AGAP5--9202
AGAP11--9307
NGEF--9344
SPATA13--9353
RAB3GAP1--9492
CCL11--9615
SYDE1--9690
TBC1D15--10227
PLEKHG2--10476
KIAA1244--10530
FGD5--10619
SPRY1--10636
PLEKHG5--10686
AGAP9--10698
PLEKHG4B--10742
TNK1--10857
SCAI--11212
CYTH3--11531
MFN2--111607
ARHGEF33--11866
ARHGAP8--11916
ASAP3--11995
FGD6--12199
ECT2L--12438
PLEKHG7--13086
FICD--13795
ARHGEF39--14085
NRAS--114119
SMAP2--14426
ARHGEF19--14560
CCL19--14578
ARHGEF15--15322
TAX1BP3--15553
RASA3--15787
AGAP10--16012
CTGLF11P--17728
ARHGEF10L--17881
ARFGAP2--18897
ARHGEF6--19241
AGAP6--19286
EPHA2--119467
ALDH1A1--19488
CDC42EP2--19500
DOCK7--19597
RASAL3--19660
ARRB1--19906
F2RL1--19969
F2R--20036
FGD2--20103
ACAP2--20167
EPO--20282
SGSM3--20539
OBSCN--20605
ARHGEF37--20661
ARHGAP15--21045
AGFG2--21063
MTOR--21095
PLEKHG1--21120
ARHGEF16--21200
SIPA1--21260
ARHGEF1--21297
ARHGAP4--21362
FBXO8--21649
CYTH4--21674
CCL21--21829
CCL24--21868
PLEKHG4--22016
RALGAPB--22093
GMIP--22274
CCR7--22367
GPR65--22555
ARHGEF5--22680
GIT2--22751
CCL26--22814
ADAP2--22843
ERBB2--123130
PLEKHG6--23259
SCRIB--23676
TBC1D2--23738
NCKAP1L--23771
VAV1--23876
ARHGAP27--23975
ECT2--24758
ARAP1--24899
ICMT--24975
ACAP1--25044
ARFGAP3--25472
PSD4--25587
FOXM1--25656
ALS2CL--25765

Network

GO:0046578

Network
Enrichment
NameDescriptionExternal IDs
PSD3pleckstrin and Sec7 domain containing 3 Entrez:23362  HGNC: 19093  Ensembl: ENSG00000156011  HPRD: 11462 
KALRNkalirin, RhoGEF kinase Entrez:8997  HPRD: 06859  HGNC: 4814  Ensembl: ENSG00000160145 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Entrez:5048  HGNC: 8574  HPRD: 03329  Ensembl: ENSG00000007168 
TRIOtrio Rho guanine nucleotide exchange factor Entrez:7204  Ensembl: ENSG00000038382  HPRD: 03537  HGNC: 12303 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PSD3pleckstrin and Sec7 domain containing 3
KALRNkalirin, RhoGEF kinase
KRASKirsten rat sarcoma viral oncogene homolog
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
TRIOtrio Rho guanine nucleotide exchange factor
Query geneGeneGene descriptionEdge score
PSD3PSD3pleckstrin and Sec7 domain containing 3
KALRNKALRNkalirin, RhoGEF kinase
KRASKRASKirsten rat sarcoma viral oncogene homolog
PAFAH1B1PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
TRIOTRIOtrio Rho guanine nucleotide exchange factor

Troyanskaya Laboratory - Princeton University