ASD

GO:0008286 insulin receptor signaling pathway (138)

GeneInput weightStandardRank
KRAS--157
YWHAB0.251107
PIK3R10.251150
FGFR2--1237
IGF1R--252
FGF9--262
ATP6V0B--277
ATP6V1G2--367
ATP6V0C0.251502
ATP6V0D1--539
SHC3--559
TSC10.251790
CAB39--797
SOS1--1810
ATP6V1A--886
MAP2K10.251907
AKT10.2511020
FOXO3--1056
MAPK1--1128
GAB1--1198
MAP2K20.2511240
IRS2--11300
BAIAP20.2511353
PIK3CA0.2511362
IRS1--11374
RPS6KB1--1521
SMARCC1--1678
PDPK1--1740
ATP6V1B2--1815
FGF1--1892
GRB10--1910
PIK3R3--1966
ATP6V0A1--2034
PRKAB2--2067
PPM1A--2070
SHC2--2256
FGFR1--2262
FGF5--2327
ATP6V1F--2424
FGF7--2591
SOCS7--2602
FGFR3--12640
CRK--2713
GRB2--2962
RAF10.2513236
EIF4G1--3374
RHEB--3728
PDE3B--3819
FGF23--13888
PRKAA2--3894
AKT2--13912
KL--3938
FOXO10.2513947
ATP6V1E1--4070
GSK3A--4141
PRKAG2--14212
FGF20--4263
AP3S1--4280
EIF4E0.2514457
FGF10--14532
ATP6V1G1--4576
SH2B2--4634
FGF3--4687
FGF4--4938
MLST8--5028
FGF17--5072
HRAS0.2515086
PIK3R2--5198
ATP6V1H--5369
INSR--15872
IGFBP1--5873
STK11--16000
PIK3R4--6073
ATP6V1D--6195
STRADA--6362
FGF18--6382
ATP6V1G3--6391
SORBS1--6411
MAPK30.2516426
FRS2--7173
PHIP--7304
ATP6V0A4--7653
PTPN11--17735
ATP6V1C2--8391
FGF16--8467
FGF8--18543
STXBP4--9119
ATP6V0D2--9130
KLB--9187
TSC20.2519351
PIK3C3--9358
FOXO4--9362
ATP6V0E2--10017
SHC1--10045
APPL1--10112
FOXC2--10175
PRKAG3--10274
ATP6V0A2--10497
ATP6V1B1--10564
CAB39L--10629
PTPN2--11261
PIK3CB--11542
BCAR1--12026
FGF19--12130
ATP6V1E2--12277
ZNF106--12789
FGF2--13150
FGF22--13277
TLR9--13360
RHOQ--14092
NRAS--114119
RPTOR--14284
FOXO6--14502
EIF4EBP2--14825
FGF6--15185
SLC2A8--19364
SREBF1--19464
FOXS1--20143
TRIB3--20863
MTOR--21095
PRKAB1--21601
ATP6V1C1--21645
INS--122047
EIF4B--22190
IGF20.25122401
EIF4EBP1--22803
PRKAA1--22917
TCIRG1--123264
STRADB--23510
FGFR4--23965
THEM4--24011
EEF2K--24194
PRKAG1--24404
DOK1--24800
NR1H3--25006
CDK1--25053
ATP6V0E1--25547
RPS6--25698

Network

GO:0008286

Network
Enrichment
NameDescriptionExternal IDs
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Entrez:5295  HGNC: 8979  Ensembl: ENSG00000145675  HPRD: 01381 
FGFR2fibroblast growth factor receptor 2 Entrez:2263  HPRD: 01492  Ensembl: ENSG00000066468  HGNC: 3689 
IGF1Rinsulin-like growth factor 1 receptor Entrez:3480  Ensembl: ENSG00000140443  HPRD: 00932  HGNC: 5465 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
KRASKirsten rat sarcoma viral oncogene homolog
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
FGFR2fibroblast growth factor receptor 2
IGF1Rinsulin-like growth factor 1 receptor
Query geneGeneGene descriptionEdge score
KRASKRASKirsten rat sarcoma viral oncogene homolog
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
PIK3R1PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
FGFR2FGFR2fibroblast growth factor receptor 2
IGF1RIGF1Rinsulin-like growth factor 1 receptor

Troyanskaya Laboratory - Princeton University