ASD

GO:0048011 nerve growth factor receptor signaling pathway (218)

GeneInput weightStandardRank
NTRK20.25151
KALRN--56
KRAS--157
CREB1--100
YWHAB0.251107
ARHGDIA--109
TRIO0.51111
PIK3R10.251150
ABR--160
ADCY2--175
PRKCE--204
AP2S1--210
ARHGEF7--215
ADCYAP1--230
ARHGEF4--265
TIAM1--325
PHLPP1--332
RASGRF1--335
CALM3--352
RPS6KA5--359
ARHGEF12--1393
GSK3B--427
MEF2C0.251428
SH3GL2--454
ADCY10.251466
RICTOR--537
SHC3--559
PRKCI--568
PRKACB--584
ITPR1--1597
RIT2--636
RPS6KA20.251689
KIDINS220--701
ARHGEF11--705
RPS6KA3--758
AP2M1--779
OMG0.251808
SOS1--1810
ARHGEF9--1875
MCF2--892
MAP2K10.251907
CAMK4--916
YWHAE--995
AKT10.2511020
PRKCA--1027
CALM1--1029
PCSK6--1035
FOXO3--1056
MCF2L--1059
MAPK1--1128
RELA--1142
CDKN1B--1162
SOS2--1181
FGD1--11182
MAPK8--1214
MAP2K20.2511240
PRKAR1B--1257
ADCYAP1R1--1273
BAD--1290
IRS2--11300
PIK3CA0.2511362
IRS1--11374
PTEN1.011389
HDAC2--1440
PRKCG--11483
CLTA--1495
RALGDS--1603
RAC1--1617
AKAP13--1679
PDPK1--1740
ITSN1--1789
ARHGEF2--1819
ADCY9--1850
PDE1C--1867
CLTC--1904
MAPK11--1962
PDE1A--1968
ELK1--2032
PRKAR2B--2211
SHC2--2256
RHOA--2292
AP2A2--2352
RASGRF2--2414
PRKAR1A--12428
DUSP6--2466
PDE1B--2534
CRK--2713
RTN4--2735
PREX1--2760
ADCY8--2785
CALM2--2814
SRC--2825
MEF2A--2837
VAV2--2850
ADCY6--2877
VAV3--2908
GRB2--2962
TIAM2--3070
ARHGEF17--3189
RAF10.2513236
NDN0.2513379
BCL2L11--3469
MAPKAPK2--3870
FOXO10.2513947
MAPK14--3975
DUSP4--4019
MAGED1--4068
PRKACG--4112
GSK3A--4141
ARHGEF3--4159
RALA--4169
ARHGEF18--4257
ADCY5--4295
MAPK7--4384
FURIN--4605
PLCG1--4744
AP2A1--4845
MAP2K5--4962
MLST8--5028
HRAS0.2515086
PIK3R2--5198
ADAM17--5323
NFKBIA--5569
ADCY3--5755
MAG--5765
RALB--5931
ADRBK1--6028
NGFR0.2516212
NGF0.2516229
RTN4R--6304
LINGO1--6321
MAPK30.2516426
PRKCD--6504
ZFYVE27--16561
MDM2--6675
CASP30.2516694
UBC--6756
AP2B1--6850
FRS2--7173
FGD4--17457
NET1--7500
CDKN1A--7714
RAPGEF1--7926
PRDM4--8037
ITPR2--8066
ADORA2A0.2518408
DUSP3--8506
NTRK10.2518522
STAT3--18538
DUSP7--8625
FGD3--8790
ADCY4--9091
NGFRAP1--9211
NGEF--9344
TSC20.2519351
FOXO4--9362
CASP2--9480
PRKACA--9630
SHC1--10045
PLEKHG2--10476
PLEKHG5--10686
TRAF6--11055
BRAF--111149
PRKAR2A--11450
PIK3CB--11542
RIT1--11848
BCAR1--12026
NR4A1--12498
HDAC1--12825
PCSK5--13062
RAP1A--13091
APH1A0.5113440
AKT1S1--13569
DNAL4--13889
NRAS--114119
SORT1--14441
PSEN1--18523
ARHGEF6--19241
UBB--19448
MAPKAP1--20094
FGD2--20103
IKBKB--20225
NFKB1--20281
PSENEN--120566
OBSCN--20605
RIPK2--20830
TRIB3--20863
NCSTN--120988
CASP90.25121044
MTOR--21095
ARHGEF16--21200
MAPK12--21269
ARHGEF1--21297
ARHGAP4--21362
IRAK1--21640
ITPR3--21697
HDAC3--21702
PSEN2--23095
MYD88--23106
RPS6KA1--23184
RPS6KB2--23226
AATF--23243
SQSTM1--123584
UTP11L--23835
VAV1--23876
THEM4--24011
MAPKAPK3--24170
ATF1--24277
SMPD2--24309
ITGB3BP--24372
RPS27A--24381
UBA52--24384
APH1B--24417
MAPK13--24490
CHUK--24756
ECT2--24758
CDK1--25053
ADCY7--25408

Network

GO:0048011

Network
Enrichment
NameDescriptionExternal IDs
NTRK2neurotrophic tyrosine kinase, receptor, type 2 Entrez:4915  Ensembl: ENSG00000148053  HPRD: 02712  HGNC: 8032 
KALRNkalirin, RhoGEF kinase Entrez:8997  HPRD: 06859  HGNC: 4814  Ensembl: ENSG00000160145 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
CREB1cAMP responsive element binding protein 1 Entrez:1385  HGNC: 2345  HPRD: 00442  Ensembl: ENSG00000118260 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
NTRK2neurotrophic tyrosine kinase, receptor, type 2
KALRNkalirin, RhoGEF kinase
KRASKirsten rat sarcoma viral oncogene homolog
CREB1cAMP responsive element binding protein 1
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Query geneGeneGene descriptionEdge score
NTRK2NTRK2neurotrophic tyrosine kinase, receptor, type 2
KALRNKALRNkalirin, RhoGEF kinase
KRASKRASKirsten rat sarcoma viral oncogene homolog
CREB1CREB1cAMP responsive element binding protein 1
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Troyanskaya Laboratory - Princeton University