ASD

GO:0051444 negative regulation of ubiquitin-protein ligase activity (72)

GeneInput weightStandardRank
PSMA1--58
PSMD14--104
PSMA4--166
PSMB3--234
PSMA5--284
PSMD8--371
PSMA3--460
PSMB1--501
PSMC6--679
PSMD6--688
PSMB7--745
PSMC2--815
PSMD11--967
PSMB4--1091
PSMD1--1168
PSMA7--1174
SMAD7--1192
BAG5--1229
PSMC4--1269
PSMC1--1296
PSMA6--1510
PSMD12--1573
PSMB6--1607
PSMD2--1706
BUB3--1718
PSMC5--1897
PSMD3--2008
PSMD4--2087
PSMC3--2240
PSMD10--2412
PSMD7--2481
PSMA2--2699
FZR1--2920
PSMD13--3051
USP44--3406
LIMK1--4265
ANAPC2--5008
UBC--6756
UBE2E1--7950
CDC27--9665
PSMB2--11986
MAD2L2--13802
PSMD9--13911
PSME2--14327
CDC23--14728
ANAPC11--14928
PSEN1--18523
UBB--19448
PSMD5--19823
CDKN2A--120587
PSME1--21072
ANAPC10--21179
PSMB9--21373
PSMB10--21853
PSMB8--22146
PSME3--22162
CDC26--22265
PSMF1--22424
RPS27A--24381
UBA52--24384
ANAPC4--24419
ANAPC7--24632
UBE2D1--24988
CDC16--24989
ANAPC1--25203
PSMB5--25250
MAD2L1--25321
ANAPC5--25367
FBXO5--25488
CDC20--25608
UBE2C--25614
BUB1B--125766

Network

GO:0051444

Network
Enrichment
NameDescriptionExternal IDs
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1 Entrez:5682  Ensembl: ENSG00000129084  HPRD: 04170  HGNC: 9530 
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 Entrez:5685  Ensembl: ENSG00000041357  HPRD: 10168  HGNC: 9533 
PSMB3proteasome (prosome, macropain) subunit, beta type, 3 Entrez:5691  HPRD: 03709  Ensembl: ENSG00000108294  HGNC: 9540 
PSMA5proteasome (prosome, macropain) subunit, alpha type, 5 Entrez:5686  Ensembl: ENSG00000143106  HGNC: 9534  HPRD: 01464 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4
PSMB3proteasome (prosome, macropain) subunit, beta type, 3
PSMA5proteasome (prosome, macropain) subunit, alpha type, 5
Query geneGeneGene descriptionEdge score
PSMA1PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMA4PSMA4proteasome (prosome, macropain) subunit, alpha type, 4
PSMB3PSMB3proteasome (prosome, macropain) subunit, beta type, 3
PSMA5PSMA5proteasome (prosome, macropain) subunit, alpha type, 5

Troyanskaya Laboratory - Princeton University