ASD

GO:0090048 negative regulation of transcription regulator activity (89)

GeneInput weightStandardRank
SUMO1--1411
PBX1--489
HDAC4--696
ZCCHC11--737
PROX1--997
BMP7--1137
SMAD7--1192
SIRT1--1233
HDAC2--1440
PTHLH--11993
ID2--2154
NR0B1--12278
PSMD10--2412
ITCH--2932
MAP3K10--2968
HR--13049
TRIB1--3431
DAB2IP--3482
TCF7L20.513548
TCEAL7--3682
PIAS4--3989
FLNA--14285
TNFAIP3--4469
CYLD--14624
CEBPG--4660
MEN1--14917
NLRP30.2514959
GLIS2--15061
PRNP--15418
PRDX2--5497
NFKBIA--5569
CTNNBIP1--5675
SIVA1--5973
TAF3--6591
RB1--16804
TNFSF4--7262
SFRP4--7310
FOXJ1--7628
XCL1--7819
DAP--8832
ID1--9040
PIM1--9182
RLIM--9269
BRMS1--9708
SIGIRR--10327
ARRB2--10647
TRAF3--11036
PYDC1--11053
GFI1--111098
SFRP5--11273
ZNF675--11676
WWP2--11885
KDM1A--12183
FOXP3--112457
WFS10.25112793
NFKBID--13229
TLR9--13360
PRMT2--13677
PEX14--113800
SETD6--13985
EGLN1--14203
NLRC3--14543
IRAK3--14633
CMKLR1--14683
DDIT3--14883
IRAK2--15024
NLRC5--19618
ARRB1--19906
FZD6--19921
PLA2G10--20040
FOXS1--20143
CDKN2A--120587
TNFRSF4--20689
COMMD7--20950
TAX1BP1--20955
NR0B2--121425
NOD2--121514
IRAK1--21640
RBCK1--22556
ID3--22679
HNF4A--122965
HMOX1--23938
COMMD1--24027
SP100--24329
TRIM21--24895
CAT--25268
RPS3--25585
DNAJA3--25610
UFL1--25631

Network

GO:0090048

Network
Enrichment
NameDescriptionExternal IDs
SUMO1small ubiquitin-like modifier 1 Entrez:7341  Ensembl: ENSG00000116030  HGNC: 12502  HPRD: 03554 
PBX1pre-B-cell leukemia homeobox 1 Entrez:5087  Ensembl: ENSG00000185630  HGNC: 8632  HPRD: 08889 
HDAC4histone deacetylase 4 Entrez:9759  Ensembl: ENSG00000068024  HPRD: 05610  HGNC: 14063 
ZCCHC11zinc finger, CCHC domain containing 11 Entrez:23318  HGNC: 28981  Ensembl: ENSG00000134744  HPRD: 15700 
PROX1prospero homeobox 1 Entrez:5629  HPRD: 03330  HGNC: 9459  Ensembl: ENSG00000117707 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SUMO1small ubiquitin-like modifier 1
PBX1pre-B-cell leukemia homeobox 1
HDAC4histone deacetylase 4
ZCCHC11zinc finger, CCHC domain containing 11
PROX1prospero homeobox 1
Query geneGeneGene descriptionEdge score
SUMO1SUMO1small ubiquitin-like modifier 1
PBX1PBX1pre-B-cell leukemia homeobox 1
HDAC4HDAC4histone deacetylase 4
ZCCHC11ZCCHC11zinc finger, CCHC domain containing 11
PROX1PROX1prospero homeobox 1

Troyanskaya Laboratory - Princeton University