ASD

GO:0045089 positive regulation of innate immune response (144)

GeneInput weightStandardRank
CREB1--100
MAPK10--1162
RPS6KA5--359
CADM10.251391
MEF2C0.251428
JUN--511
MAP2K4--567
RPS6KA20.251689
UBE2N--734
RPS6KA3--758
TAB2--785
MAP2K10.251907
TRIL--966
MAPK1--1128
RELA--1142
MAPK8--1214
MAP2K20.2511240
MAP3K7--1275
ATF2--1309
TXN--1408
APP--1515
FOS--1680
MAPK11--1962
ELK1--2032
MAPK9--2237
DUSP6--2466
BCL20.2512485
STAT5B--2593
MEF2A--2837
ITCH--2932
PELI2--3014
PELI1--3259
MAP3K1--13381
IL12B--3596
TAB3--3641
MAPKAPK2--3870
HSP90AB1--3924
MAPK14--3975
DUSP4--4019
IRF3--4175
MAPK7--4384
TNFAIP3--4469
IL21--4601
CYLD--14624
HSPD1--14908
NLRP30.2514959
IFNB1--5250
NFKBIA--5569
MAP2K7--5837
CD226--5866
MAPK30.2516426
BCL2L1--6563
UBC--6756
NLRC4--7212
TAB1--7218
MEFV--17860
P2RX7--7888
DUSP3--8506
DUSP7--8625
PVRL2--8977
EREG--9052
IFNK--9592
TLR8--10002
TXNIP--10069
MAP2K6--10478
IL12A--10482
TBK1--10660
GIMAP5--10690
TLR6--10981
COLEC12--10987
UBE2V1--11027
TRAF3--11036
TRAF6--11055
TLR10--11746
TLR4--112795
CRTAM--13317
TLR7--13389
AIM2--13450
MAP2K3--13704
SH2D1A--13947
NCR3--14308
IRAK3--14633
IRAK2--15024
LAG3--15302
NFKB2--15507
CLEC7A--115738
MICA--18885
KLRK1--19104
TLR2--119246
UBB--19448
IKBKB--20225
NFKB1--20281
TLR5--20283
NLRP1--20532
LBP--20559
TIRAP--20658
CD86--20696
RIPK2--20830
PANX1--21011
STAT5A--21176
CD1D--21452
NOD2--121514
TLR1--21623
IRAK1--21640
ADAM8--21797
TICAM1--21880
MARCO--22113
SUGT1--22142
PYCARD--22145
BCL10--122368
TLR3--22478
RIPK1--22681
PVR--22699
NFKBIB--22875
CCL5--23042
MYD88--23106
IRAK4--23154
RPS6KA1--23184
PSTPIP1--23191
LY96--23247
MAVS--23348
NOD1--23388
IKBKG--123539
CARD9--123577
POLR3D--23700
UNC93B1--23927
MAPKAPK3--24170
POLR3B--24265
ATF1--24277
RPS27A--24381
UBA52--24384
IRF7--24488
DMBT1--24546
CASP8--124587
TMEM173--24599
POLR3G--24642
IKBKE--24643
POLR3C--24655
CHUK--24756
POLR3F--24855
CDK1--25053
S100A14--25078
TICAM2--25440
CASP1--25470

Network

GO:0045089

Network
Enrichment
NameDescriptionExternal IDs
CREB1cAMP responsive element binding protein 1 Entrez:1385  HGNC: 2345  HPRD: 00442  Ensembl: ENSG00000118260 
MAPK10mitogen-activated protein kinase 10 Entrez:5602  HGNC: 6872  Ensembl: ENSG00000109339  HPRD: 04207 
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5 Entrez:9252  Ensembl: ENSG00000100784  HPRD: 06789  HGNC: 10434 
CADM1cell adhesion molecule 1 Entrez:23705  HGNC: 5951  HPRD: 05746  Ensembl: ENSG00000182985 
MEF2Cmyocyte enhancer factor 2C Entrez:4208  HGNC: 6996  Ensembl: ENSG00000081189  HPRD: 02809 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CREB1cAMP responsive element binding protein 1
MAPK10mitogen-activated protein kinase 10
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5
CADM1cell adhesion molecule 1
MEF2Cmyocyte enhancer factor 2C
Query geneGeneGene descriptionEdge score
CREB1CREB1cAMP responsive element binding protein 1
MAPK10MAPK10mitogen-activated protein kinase 10
RPS6KA5RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5
CADM1CADM1cell adhesion molecule 1
MEF2CMEF2Cmyocyte enhancer factor 2C

Troyanskaya Laboratory - Princeton University