ASD

GO:0002698 negative regulation of immune effector process (41)

GeneInput weightStandardRank
ABR--160
SOCS5--463
TGFB2--834
PPP3CB--1731
BCR--11839
MASP1--2021
RC3H1--2217
BCL6--2550
ITCH--2932
FOXF1--13518
IRF3--4175
IL2RA--4611
DUSP10--5172
IFNB1--5250
PCBP2--6256
NDFIP1--6744
TNFSF4--7262
FOXJ1--7628
IFNA2--7694
XCL1--7819
IFNL1--10151
TAP1--110380
ARRB2--10647
SPN--12057
FOXP3--112457
TGFB3--113097
IRAK3--14633
TGFB10.25120135
JAK3--20340
IL4R--20610
NOD2--121514
PTPRC--21546
IL20RB--22045
INS--122047
CCR2--23296
HMOX1--23938
A2M--24058
IFIT1--24398
TARBP2--24667
MICB--25021
SERPING1--125126

Network

GO:0002698

Network
Enrichment
NameDescriptionExternal IDs
ABRactive BCR-related Entrez:29  HGNC: 81  HPRD: 02649  Ensembl: ENSG00000159842 
SOCS5suppressor of cytokine signaling 5 Entrez:9655  HPRD: 06159  HGNC: 16852  Ensembl: ENSG00000171150 
TGFB2transforming growth factor, beta 2 Entrez:7042  HGNC: 11768  Ensembl: ENSG00000092969  HPRD: 01828 
PPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme Entrez:5532  Ensembl: ENSG00000107758  HGNC: 9315  HPRD: 00235 
BCRbreakpoint cluster region Entrez:613  HGNC: 1014  HPRD: 01044  Ensembl: ENSG00000186716 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
ABRactive BCR-related
SOCS5suppressor of cytokine signaling 5
TGFB2transforming growth factor, beta 2
PPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme
BCRbreakpoint cluster region
Query geneGeneGene descriptionEdge score
ABRABRactive BCR-related
SOCS5SOCS5suppressor of cytokine signaling 5
TGFB2TGFB2transforming growth factor, beta 2
PPP3CBPPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme
BCRBCRbreakpoint cluster region

Troyanskaya Laboratory - Princeton University