ASD

GO:0007173 epidermal growth factor receptor signaling pathway (77)

GeneInput weightStandardRank
KRAS--157
YWHAB0.251107
PIK3R10.251150
HGS--152
AP2S1--210
ARHGEF7--215
RPS6KA5--359
SH3GL2--454
SOCS5--463
SHC3--559
AP2M1--779
SOS1--1810
MAP2K10.251907
SOX9--1970
MAPK1--1128
CDC42--1138
GAB1--1198
MAP2K20.2511240
PIK3CA0.2511362
SPRY2--1454
CBL--1478
CLTA--1495
TGFA--1873
CLTC--1904
ERBB2IP--1926
EPS15L1--2046
AP2A2--2352
EGFR--12546
SRC--2825
GRB2--2962
PTK2B--3063
NCK2--3077
RAF10.2513236
CAMLG--3813
HBEGF--3865
SH3KBP1--4166
REPS2--4330
ADAM12--4712
PLCG1--4744
DGKD--4786
AP2A1--4845
HRAS0.2515086
EPS15--5197
ADAM17--5323
PAG1--5486
MAPK30.2516426
UBC--6756
PXN--6823
AP2B1--6850
PLCE1--6929
STAM--7024
RAB7A--17223
PTPN11--17735
ARF4--8507
AREG--8583
EREG--9052
SHC1--10045
SPRY1--10636
BCAR1--12026
EGF0.25112881
CSK--14028
NRAS--114119
UBB--19448
AREGB--19783
EPN1--19827
TGFB10.25120135
GRB7--20514
ADAM10--20986
EPS8--21085
VIL10.5122243
KIF16B--22922
ERBB2--123130
STAM2--23860
RPS27A--24381
UBA52--24384
CDK1--25053
EFEMP1--25366

Network

GO:0007173

Network
Enrichment
NameDescriptionExternal IDs
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Entrez:5295  HGNC: 8979  Ensembl: ENSG00000145675  HPRD: 01381 
HGShepatocyte growth factor-regulated tyrosine kinase substrate Entrez:9146  Ensembl: ENSG00000185359  HPRD: 05085  HGNC: 4897 
AP2S1adaptor-related protein complex 2, sigma 1 subunit Entrez:1175  HPRD: 03762  Ensembl: ENSG00000042753  HGNC: 565 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
KRASKirsten rat sarcoma viral oncogene homolog
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
HGShepatocyte growth factor-regulated tyrosine kinase substrate
AP2S1adaptor-related protein complex 2, sigma 1 subunit
Query geneGeneGene descriptionEdge score
KRASKRASKirsten rat sarcoma viral oncogene homolog
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
PIK3R1PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
HGSHGShepatocyte growth factor-regulated tyrosine kinase substrate
AP2S1AP2S1adaptor-related protein complex 2, sigma 1 subunit

Troyanskaya Laboratory - Princeton University