ASD

GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway (107)

GeneInput weightStandardRank
CREB1--100
BMPR2--1281
ACVR1B--510
JUN--511
UBE2D3--528
USP9X--554
NLK--712
ZFYVE9--795
SMAD4--821
SMAD3--823
TGFB2--834
PTPRK--850
SMURF2--889
CHRD--941
ACVR2A--965
SMAD5--1002
HIPK2--1051
BMP7--1137
BMPR1A--1140
SMAD7--1192
MAP3K7--1275
FKBP1A--1284
LEF1--1499
GDF10--1535
ACVR2B--11676
FOS--1680
SMAD1--1872
MSX2--12260
GDF6--12291
SMAD6--2305
BMPR1B--12316
CHRDL1--2383
LEFTY1--2443
GREM2--2664
SMAD2--2694
RGMB--2696
INHBB--2842
SKI--2904
SMURF1--3060
EGR1--3062
CITED1--3064
MSX1--13127
NODAL--13149
T--3286
MAP3K1--13381
KLF10--3457
SPTBN1--3627
SMAD9--13672
PDGFA--3731
STUB1--4250
MSTN--4329
BMP6--4358
WNT1--4383
FURIN--4605
TGFBRAP1--4795
BMP2--14855
GDF5--14882
BMP10--5102
NOG--15439
ZFYVE16--5592
WFIKKN2--5598
PPM1L--5788
ACVR1--16054
GDF9--6335
BMP4--16499
USP9Y--16508
AKAP3--6566
TGFBR3--6672
GDF7--6682
CER1--6956
TAB1--7218
TGFBR1--17268
LEFTY2--7335
AKAP4--8051
AMHR2--8485
ID1--9040
TGFBR2--110407
ARRB2--10647
FOXH1--10963
AFP--11538
ACVRL1--111656
GATA4--112466
FSHB0.25112923
TGFB3--113097
FSTL1--14291
GDF2--14603
FST--14783
FNTA--14922
POU5F1--19704
TGFB10.25120135
GDF15--20185
PDGFB--21071
EID2--21599
IRAK1--21640
HPGD--122284
ECSIT--22627
COL1A2--122629
COL3A1--122855
HNF4A--122965
FMOD--23581
TGFB1I1--23709
ENG--124746
DUSP22--24825
UBE2D1--24988
ADAM9--125221
PML--25277
LTBP2--125618

Network

GO:0007178

Network
Enrichment
NameDescriptionExternal IDs
CREB1cAMP responsive element binding protein 1 Entrez:1385  HGNC: 2345  HPRD: 00442  Ensembl: ENSG00000118260 
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) Entrez:659  Ensembl: ENSG00000204217  HPRD: 02880  HGNC: 1078 
ACVR1Bactivin A receptor, type IB Entrez:91  Ensembl: ENSG00000135503  HGNC: 172  HPRD: 03193 
JUNjun proto-oncogene Entrez:3725  HGNC: 6204  HPRD: 01302  Ensembl: ENSG00000177606 
UBE2D3ubiquitin-conjugating enzyme E2D 3 Entrez:7323  Ensembl: ENSG00000109332  HPRD: 04269  HGNC: 12476 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CREB1cAMP responsive element binding protein 1
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)
ACVR1Bactivin A receptor, type IB
JUNjun proto-oncogene
UBE2D3ubiquitin-conjugating enzyme E2D 3
Query geneGeneGene descriptionEdge score
CREB1CREB1cAMP responsive element binding protein 1
BMPR2BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)
ACVR1BACVR1Bactivin A receptor, type IB
JUNJUNjun proto-oncogene
UBE2D3UBE2D3ubiquitin-conjugating enzyme E2D 3

Troyanskaya Laboratory - Princeton University