ASD

GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger (54)

GeneInput weightStandardRank
GNB1--24
HTR2A0.251121
GNAQ--189
GRM50.251240
CRHR1--589
CCKBR--794
DRD10.251899
NTSR2--920
CALCA--1013
DRD50.2511103
ADRA2A0.2511399
PTGER3--1587
GNG13--1774
ADRA1A--1858
HCRTR20.2511860
NMBR--2016
EDNRB--12042
GNA11--2281
CHRM2--2799
LHCGR0.2513057
HOMER10.2513402
GNA14--3634
DRD20.2513749
EDNRA--13857
LPAR1--4170
S1PR1--4301
P2RY1--4342
NPR3--5370
AGTR1--16275
NMUR2--6430
CHRM1--6796
PLCE1--6929
RXFP3--6996
P2RY4--7298
HRH1--7471
MC3R0.2518188
GPR139--8207
EDN1--9540
F2RL3--9626
TACR1--11618
HCRT0.25111633
CCKAR--11747
LPAR3--11897
AGT--113305
CXCR2--15438
NMUR1--19043
LTB4R--19987
F2R--20036
P2RY11--20669
GNA15--20926
SLC9A3R1--21898
P2RY6--23098
TGM2--23204
P2RY2--24088

Network

GO:0007200

Network
Enrichment
NameDescriptionExternal IDs
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1 Entrez:2782  HGNC: 4396  HPRD: 00766  Ensembl: ENSG00000078369 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
GNAQguanine nucleotide binding protein (G protein), q polypeptide Entrez:2776  HGNC: 4390  HPRD: 02998 
GRM5glutamate receptor, metabotropic 5 Entrez:2915  HGNC: 4597  Ensembl: ENSG00000168959 
CRHR1corticotropin releasing hormone receptor 1 Entrez:1394  Ensembl: ENSG00000120088  HGNC: 2357  HPRD: 08830 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
GNAQguanine nucleotide binding protein (G protein), q polypeptide
GRM5glutamate receptor, metabotropic 5
CRHR1corticotropin releasing hormone receptor 1
Query geneGeneGene descriptionEdge score
GNB1GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
GNAQGNAQguanine nucleotide binding protein (G protein), q polypeptide
GRM5GRM5glutamate receptor, metabotropic 5
CRHR1CRHR1corticotropin releasing hormone receptor 1

Troyanskaya Laboratory - Princeton University