ASD

GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway (14)

GeneInput weightStandardRank
CNTN2--674
TMOD2--2615
DRD20.2513749
PDE6H--4126
GSK3A--4141
DRD30.2514349
LRRK2--18802
KLK6--10748
PTGDR2--10914
KLK14--19554
KLK5--20016
PDE6G--120364
ECE1--120540
CAV2--25271

Network

GO:0045745

Network
Enrichment
NameDescriptionExternal IDs
CNTN2contactin 2 (axonal) Entrez:6900  HGNC: 2172  Ensembl: ENSG00000184144  HPRD: 01826 
TMOD2tropomodulin 2 (neuronal) Entrez:29767  Ensembl: ENSG00000128872  HGNC: 11872  HPRD: 04237 
DRD2dopamine receptor D2 Entrez:1813  HPRD: 00539  Ensembl: ENSG00000149295  HGNC: 3023 
PDE6Hphosphodiesterase 6H, cGMP-specific, cone, gamma Entrez:5149  HGNC: 8790  HPRD: 03116  Ensembl: ENSG00000139053 
GSK3Aglycogen synthase kinase 3 alpha Entrez:2931  HGNC: 4616  HPRD: 06002  Ensembl: ENSG00000105723 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CNTN2contactin 2 (axonal)
TMOD2tropomodulin 2 (neuronal)
DRD2dopamine receptor D2
PDE6Hphosphodiesterase 6H, cGMP-specific, cone, gamma
GSK3Aglycogen synthase kinase 3 alpha
Query geneGeneGene descriptionEdge score
CNTN2CNTN2contactin 2 (axonal)
TMOD2TMOD2tropomodulin 2 (neuronal)
DRD2DRD2dopamine receptor D2
PDE6HPDE6Hphosphodiesterase 6H, cGMP-specific, cone, gamma
GSK3AGSK3Aglycogen synthase kinase 3 alpha

Troyanskaya Laboratory - Princeton University