ASD

GO:0030162 regulation of proteolysis (146)

GeneInput weightStandardRank
PSMD14--104
PIK3R10.251150
FBXW7--198
EP300--1318
SUMO1--1411
TRIB2--472
OGT--477
RAD23B--658
CNTN2--674
RPS6KA20.251689
CSNK1D--699
MGEA5--732
CSNK1E0.251752
FBXW11--859
AKT10.2511020
SMAD7--1192
USP14--1209
BAG6--1305
PTEN1.011389
ADRA2A0.2511399
HDAC2--1440
WNT10B--1517
RCHY1--1615
N4BP1--1749
BTRC--1884
UBE2V2--1939
SERPINI1--2010
MASP1--2021
PSMD10--2412
C2CD3--2994
USP44--3406
TRIB1--3431
SERPINE2--3708
HSP90AB1--3924
SUMO2--4064
GLG1--4233
STUB1--4250
RNF180--4255
WNT1--4383
AXIN1--14419
FURIN--4605
PTPN3--4627
SERPINI2--4888
SERPINB10--5376
PRICKLE1--15552
SERPINA4--5609
SERPINB13--5869
DNAJB2--6026
SERPINA7--6130
NR1H2--6183
CLN8--16415
MDM2--6675
SH3D19--6906
VCP--7434
SERPINB12--7487
SERPIND1--8483
TIMP1--8520
C6--8602
LRRK2--18802
SERPINB11--9075
IL10--19513
SERPINA2P--9691
HSPBP1--9785
TRIM320.2519794
SERPINA9--9848
SERPINA12--9849
USP5--9852
GIPC1--9877
CLN3--110442
SERPINA10--10447
TAF9--10627
TAF1--10729
IL1B--110818
TRAF3--11036
GPX10.25111644
RAD23A--11998
SERPINB8--12270
GCLC--12360
SERPINA6--12381
IFT88--12504
SERPINB4--12643
WFS10.25112793
IFNG--112827
KLKB1--12910
SERPINE3--12926
SERPINB9--13041
DYX1C10.25113222
AGT--113305
MAD2L2--13802
SERPINC1--14073
AURKAIP1--14217
SPINK9--14309
SERPINA11--14361
TNF0.25115243
SERPINA13P--15425
SERPINB2--15479
IFT52--16599
HDAC6--16779
PSEN1--18523
SERPINB3--18550
SHH--118571
F2--118599
SERPINF2--18906
GSAP--20423
SERPINA5--20717
PLAUR--20792
RAB23--20831
PACSIN3--21093
F12--121126
SERPINA3--21453
NRD1--21456
NUB1--21779
ADAM8--21797
INS--122047
PSME3--22162
SERPINB7--22262
SERPINA1--122405
PLAT--22444
SERPINB5--22491
UCHL5--22745
RHBDF1--23088
GNB2L1--23282
APOE0.25123516
FBXO22--23669
UBXN1--23735
TIMP3--23921
CLN6--124022
COMMD1--24027
A2M--24058
SERPINB6--124104
DNAJC1--24415
THBS1--24444
SERPINB1--24917
LTBP4--25003
SERPINE10.25125055
SERPINF1--25093
SERPING1--125126
PLGRKT--25130
ADAM9--125221
PML--25277
MAD2L1--25321
DAB2--25338
CLU--25437
IDE--25443
SERPINH1--25570
PLK1--25783

Network

GO:0030162

Network
Enrichment
NameDescriptionExternal IDs
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Entrez:5295  HGNC: 8979  Ensembl: ENSG00000145675  HPRD: 01381 
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Entrez:55294  HPRD: 05888  Ensembl: ENSG00000109670  HGNC: 16712 
EP300E1A binding protein p300 Entrez:2033  Ensembl: ENSG00000100393  HGNC: 3373  HPRD: 04078 
SUMO1small ubiquitin-like modifier 1 Entrez:7341  Ensembl: ENSG00000116030  HGNC: 12502  HPRD: 03554 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
EP300E1A binding protein p300
SUMO1small ubiquitin-like modifier 1
Query geneGeneGene descriptionEdge score
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PIK3R1PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
FBXW7FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
EP300EP300E1A binding protein p300
SUMO1SUMO1small ubiquitin-like modifier 1

Troyanskaya Laboratory - Princeton University