GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator (10)

GeneInput weightStandardRank
SIRT1--1233
MIF0.2511552
PSMD10--2412
MDM2--6675
TWIST1--16980
SNAI1--9198
KDM1A--12183
CD44--20701
SNAI2--123962
CD74--24030

Network

GO:0043518

Network
Enrichment
NameDescriptionExternal IDs
SIRT1sirtuin 1 Entrez:23411  Ensembl: ENSG00000096717  HPRD: 08381  HGNC: 14929 
MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor) Entrez:4282  HGNC: 7097  HPRD: 01091 
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Entrez:5716  HPRD: 04594  HGNC: 9555  Ensembl: ENSG00000101843 
MDM2MDM2 oncogene, E3 ubiquitin protein ligase Entrez:4193  HPRD: 01272  Ensembl: ENSG00000135679  HGNC: 6973 
TWIST1twist basic helix-loop-helix transcription factor 1 Entrez:7291  HPRD: 03374  HGNC: 12428  Ensembl: ENSG00000122691 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SIRT1sirtuin 1
MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
MDM2MDM2 oncogene, E3 ubiquitin protein ligase
TWIST1twist basic helix-loop-helix transcription factor 1
Query geneGeneGene descriptionEdge score
SIRT1SIRT1sirtuin 1
MIFMIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)
PSMD10PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
MDM2MDM2MDM2 oncogene, E3 ubiquitin protein ligase
TWIST1TWIST1twist basic helix-loop-helix transcription factor 1