ASD

GO:0042176 regulation of protein catabolic process (120)

GeneInput weightStandardRank
PPP2CA--20
GRIN2A0.25166
PSMD14--104
HGS--152
FBXW7--198
APC0.251266
SUMO1--1411
GSK3B--427
TRIB2--472
NEDD4L--495
RAD23B--658
CSNK1D--699
CSNK1E0.251752
SMAD4--821
SMAD3--823
FYN--932
SOX9--1970
AKT10.2511020
XPO1--1095
CDC42--1138
RELA--1142
CBLB--1161
CDKN1B--1162
PSMD1--1168
SMAD7--1192
USP14--1209
BAG6--1305
PTEN1.011389
ADRA2A0.2511399
PRKCG--11483
WNT10B--1517
RCHY1--1615
PSMD2--1706
N4BP1--1749
BTRC--1884
UBE2V2--1939
PSMD3--2008
AGAP2--2378
PSMD10--2412
FZR1--2920
ITCH--2932
MYLIP--3008
WNT5A--3319
USP44--3406
TRIB1--3431
ARNTL--3493
SERPINE2--3708
HSP90AB1--3924
SOX17--4024
SUMO2--4064
GSK3A--4141
STUB1--4250
RNF180--4255
FLNA--14285
WNT1--4383
AXIN1--14419
TNFAIP3--4469
FURIN--4605
PTPN3--4627
BARD1--15343
PRICKLE1--15552
GRIN2C--5801
DNAJB2--6026
MDM2--6675
NDFIP1--6744
SH3D19--6906
VCP--7434
SERPINB12--7487
MDM4--7770
GPC3--18430
TIMP1--8520
LRRK2--18802
IL10--19513
HSPBP1--9785
TRIM320.2519794
USP5--9852
MAPK15--9863
GIPC1--9877
TAF9--10627
TAF1--10729
PCSK9--10760
IL1B--110818
NOS20.25111577
GPX10.25111644
RAD23A--11998
EGLN2--12215
GCLC--12360
IFNG--112827
DYX1C10.25113222
MAD2L2--13802
GJA10.25113867
NEDD40.25114040
UBXN2A--14277
IRAK3--14633
TNF0.25115243
PSEN1--18523
SHH--118571
SNX1--20239
SGSM3--20539
PACSIN3--21093
NRD1--21456
NUB1--21779
ADAM8--21797
INS--122047
PSME3--22162
UCHL5--22745
RHBDF1--23088
GNB2L1--23282
FAF1--23304
APOE0.25123516
FBXO22--23669
UBXN1--23735
TIMP3--23921
COMMD1--24027
ADAM9--125221
PML--25277
MAD2L1--25321
DAB2--25338
CLU--25437
PLK1--25783

Network

GO:0042176

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A Entrez:2903  HGNC: 4585  Ensembl: ENSG00000183454  HPRD: 00698 
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
HGShepatocyte growth factor-regulated tyrosine kinase substrate Entrez:9146  Ensembl: ENSG00000185359  HPRD: 05085  HGNC: 4897 
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Entrez:55294  HPRD: 05888  Ensembl: ENSG00000109670  HGNC: 16712 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
HGShepatocyte growth factor-regulated tyrosine kinase substrate
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GRIN2AGRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
HGSHGShepatocyte growth factor-regulated tyrosine kinase substrate
FBXW7FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

Troyanskaya Laboratory - Princeton University