ASD

GO:0032007 negative regulation of TOR signaling cascade (9)

GeneInput weightStandardRank
TSC10.251790
DDIT4--3443
UBR2--4054
GSK3A--4141
UBR1--15553
TSC20.2519351
DEPTOR--10635
AKT1S1--13569
TMEM127--22217

Network

GO:0032007

Network
Enrichment
NameDescriptionExternal IDs
TSC1tuberous sclerosis 1 Entrez:7248  Ensembl: ENSG00000165699  HGNC: 12362  HPRD: 05594 
DDIT4DNA-damage-inducible transcript 4 Entrez:54541  HGNC: 24944  Ensembl: ENSG00000168209  HPRD: 09662 
UBR2ubiquitin protein ligase E3 component n-recognin 2 Entrez:23304  HGNC: 21289  HPRD: 09853  Ensembl: ENSG00000024048 
GSK3Aglycogen synthase kinase 3 alpha Entrez:2931  HGNC: 4616  HPRD: 06002  Ensembl: ENSG00000105723 
UBR1ubiquitin protein ligase E3 component n-recognin 1 Entrez:197131  HGNC: 16808  HPRD: 09342  Ensembl: ENSG00000159459 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
TSC1tuberous sclerosis 1
DDIT4DNA-damage-inducible transcript 4
UBR2ubiquitin protein ligase E3 component n-recognin 2
GSK3Aglycogen synthase kinase 3 alpha
UBR1ubiquitin protein ligase E3 component n-recognin 1
Query geneGeneGene descriptionEdge score
TSC1TSC1tuberous sclerosis 1
DDIT4DDIT4DNA-damage-inducible transcript 4
UBR2UBR2ubiquitin protein ligase E3 component n-recognin 2
GSK3AGSK3Aglycogen synthase kinase 3 alpha
UBR1UBR1ubiquitin protein ligase E3 component n-recognin 1

Troyanskaya Laboratory - Princeton University