ASD

GO:0008633 activation of pro-apoptotic gene products (31)

GeneInput weightStandardRank
YWHAB0.251107
PPP3R1--321
SMAD3--823
AKT10.2511020
DYNLL1--1191
MAPK8--1214
BAD--1290
BCL20.2512485
CDK50.2513194
BCL2L11--3469
FASLG--15523
BMF--6376
PMAIP1--7385
NMT1--8219
BAX--9833
DEDD2--12101
TNFRSF10B--13570
PPP3CC--16922
BBC3--20534
GZMB--20809
DYNLL2--21102
BAK1--21229
BID--22640
RIPK1--22681
FADD--23261
TRAF2--23686
IFI27--23825
CASP8--124587
FAS--124697
TNFSF10--25200
TRADD--25265

Network

GO:0008633

Network
Enrichment
NameDescriptionExternal IDs
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
PPP3R1protein phosphatase 3, regulatory subunit B, alpha Entrez:5534  HPRD: 03195  HGNC: 9317  Ensembl: ENSG00000221823 
SMAD3SMAD family member 3 Entrez:4088  HPRD: 04380  HGNC: 6769  Ensembl: ENSG00000166949 
AKT1v-akt murine thymoma viral oncogene homolog 1 Entrez:207  HPRD: 01261  Ensembl: ENSG00000142208  HGNC: 391 
DYNLL1dynein, light chain, LC8-type 1 Entrez:8655  HGNC: 15476  HPRD: 03334  Ensembl: ENSG00000088986 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
PPP3R1protein phosphatase 3, regulatory subunit B, alpha
SMAD3SMAD family member 3
AKT1v-akt murine thymoma viral oncogene homolog 1
DYNLL1dynein, light chain, LC8-type 1
Query geneGeneGene descriptionEdge score
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
PPP3R1PPP3R1protein phosphatase 3, regulatory subunit B, alpha
SMAD3SMAD3SMAD family member 3
AKT1AKT1v-akt murine thymoma viral oncogene homolog 1
DYNLL1DYNLL1dynein, light chain, LC8-type 1

Troyanskaya Laboratory - Princeton University