ASD

GO:0051898 negative regulation of protein kinase B signaling cascade (13)

GeneInput weightStandardRank
IGF1R--252
PTEN1.011389
DAG1--3580
KLF4--3609
DRD20.2513749
PLEKHA1--3930
DRD30.2514349
PTPRJ--19136
TSC20.2519351
SFRP5--11273
EPHA2--119467
SLC9A3R1--21898
PHLDA3--24856

Network

GO:0051898

Network
Enrichment
NameDescriptionExternal IDs
IGF1Rinsulin-like growth factor 1 receptor Entrez:3480  Ensembl: ENSG00000140443  HPRD: 00932  HGNC: 5465 
PTENphosphatase and tensin homolog Entrez:5728  HGNC: 9588  HPRD: 03431 
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1) Entrez:1605  HPRD: 00546  Ensembl: ENSG00000173402  HGNC: 2666 
KLF4Kruppel-like factor 4 (gut) Entrez:9314  HGNC: 6348  Ensembl: ENSG00000136826 
DRD2dopamine receptor D2 Entrez:1813  HPRD: 00539  Ensembl: ENSG00000149295  HGNC: 3023 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
IGF1Rinsulin-like growth factor 1 receptor
PTENphosphatase and tensin homolog
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)
KLF4Kruppel-like factor 4 (gut)
DRD2dopamine receptor D2
Query geneGeneGene descriptionEdge score
IGF1RIGF1Rinsulin-like growth factor 1 receptor
PTENPTENphosphatase and tensin homolog
DAG1DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)
KLF4KLF4Kruppel-like factor 4 (gut)
DRD2DRD2dopamine receptor D2

Troyanskaya Laboratory - Princeton University