ASD

GO:2000344 positive regulation of acrosome reaction (5)

GeneInput weightStandardRank
PLCB1--148
GLRA1--2965
CACNA1H1.013855
ZP4--14747
ZP3--17443

Network

GO:2000344

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
GLRA1glycine receptor, alpha 1 Entrez:2741  Ensembl: ENSG00000145888  HPRD: 00719  HGNC: 4326 
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit Entrez:8912  HPRD: 07442  HGNC: 1395  Ensembl: ENSG00000196557 
ZP4zona pellucida glycoprotein 4 Entrez:57829  HPRD: 18363  HGNC: 15770 
ZP3zona pellucida glycoprotein 3 (sperm receptor) Entrez:7784  Ensembl: ENSG00000188372  HPRD: 01690  HGNC: 13189 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GLRA1glycine receptor, alpha 1
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit
ZP4zona pellucida glycoprotein 4
ZP3zona pellucida glycoprotein 3 (sperm receptor)
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GLRA1GLRA1glycine receptor, alpha 1
CACNA1HCACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit
ZP4ZP4zona pellucida glycoprotein 4
ZP3ZP3zona pellucida glycoprotein 3 (sperm receptor)

Troyanskaya Laboratory - Princeton University