ASD

GO:0046626 regulation of insulin receptor signaling pathway (22)

GeneInput weightStandardRank
PRKCZ--991
RELA--1142
IRS1--11374
RPS6KB1--1521
GRB10--1910
PTPRE--3004
GSK3A--4141
PTPN1--14239
INPPL1--4681
PTPRF--5040
ENPP1--16091
PRKCD--6504
GRB14--6589
TSC20.2519351
SOCS1--9583
IL1B--110818
AHSG--11515
LEP0.25111864
SIK2--13619
INS--122047
IGF20.25122401
SOCS3--22661

Network

GO:0046626

Network
Enrichment
NameDescriptionExternal IDs
PRKCZprotein kinase C, zeta Entrez:5590  Ensembl: ENSG00000067606  HPRD: 01504  HGNC: 9412 
RELAv-rel avian reticuloendotheliosis viral oncogene homolog A Entrez:5970  HGNC: 9955  HPRD: 01241  Ensembl: ENSG00000173039 
IRS1insulin receptor substrate 1 Entrez:3667  HPRD: 00943  HGNC: 6125 
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 1 Entrez:6198  Ensembl: ENSG00000108443  HGNC: 10436  HPRD: 10202 
GRB10growth factor receptor-bound protein 10 Entrez:2887  Ensembl: ENSG00000106070  HGNC: 4564  HPRD: 03312 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PRKCZprotein kinase C, zeta
RELAv-rel avian reticuloendotheliosis viral oncogene homolog A
IRS1insulin receptor substrate 1
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 1
GRB10growth factor receptor-bound protein 10
Query geneGeneGene descriptionEdge score
PRKCZPRKCZprotein kinase C, zeta
RELARELAv-rel avian reticuloendotheliosis viral oncogene homolog A
IRS1IRS1insulin receptor substrate 1
RPS6KB1RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 1
GRB10GRB10growth factor receptor-bound protein 10

Troyanskaya Laboratory - Princeton University