ASD

GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (56)

GeneInput weightStandardRank
SOX11--96
BMPR2--1281
ACVR1B--510
SMAD4--821
ACVR2A--965
HIPK2--1051
BMP7--1137
BMPR1A--1140
ACVR2B--11676
GDF6--12291
CITED2--2650
CDKN1C--12938
CITED1--3064
ITGA8--3626
BMP6--4358
FURIN--4605
BMP2--14855
MEN1--14917
HES5--4919
BMP10--5102
ADAM17--5323
HES10.2515912
STK11--16000
FOXD2--6176
NPNT--6188
BMP4--16499
TGFBR3--6672
GDF7--6682
TGFBR1--17268
ILK--7305
FOXD4L1--7836
FOXD1--7884
GPC3--18430
FOXD4L4--9599
GIPC1--9877
GATA6--110828
FOXD4--11635
ACVRL1--111656
FBXL15--12126
GATA4--112466
TGFB3--113097
FOXD4L5--13951
GDF2--14603
CDKN2B--14806
RBPMS--14967
FOXD4L2--16505
FOXD4L6--19555
POU5F1--19704
TGFB10.25120135
ING2--21967
CYR61--22574
TGFB1I1--23709
THBS1--24444
ENG--124746
TWSG1--24840
TTK--25648

Network

GO:0090100

Network
Enrichment
NameDescriptionExternal IDs
SOX11SRY (sex determining region Y)-box 11 Entrez:6664  HGNC: 11191  Ensembl: ENSG00000176887  HPRD: 02940 
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) Entrez:659  Ensembl: ENSG00000204217  HPRD: 02880  HGNC: 1078 
ACVR1Bactivin A receptor, type IB Entrez:91  Ensembl: ENSG00000135503  HGNC: 172  HPRD: 03193 
SMAD4SMAD family member 4 Entrez:4089  Ensembl: ENSG00000141646  HGNC: 6770  HPRD: 02995 
ACVR2Aactivin A receptor, type IIA Entrez:92  HGNC: 173  HPRD: 00025  Ensembl: ENSG00000121989 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SOX11SRY (sex determining region Y)-box 11
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)
ACVR1Bactivin A receptor, type IB
SMAD4SMAD family member 4
ACVR2Aactivin A receptor, type IIA
Query geneGeneGene descriptionEdge score
SOX11SOX11SRY (sex determining region Y)-box 11
BMPR2BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)
ACVR1BACVR1Bactivin A receptor, type IB
SMAD4SMAD4SMAD family member 4
ACVR2AACVR2Aactivin A receptor, type IIA

Troyanskaya Laboratory - Princeton University