ASD

GO:0002221 pattern recognition receptor signaling pathway (96)

GeneInput weightStandardRank
CREB1--100
MAPK10--1162
RPS6KA5--359
MEF2C0.251428
JUN--511
MAP2K4--567
RPS6KA20.251689
UBE2N--734
RPS6KA3--758
TAB2--785
MAP2K10.251907
TRIL--966
MAPK1--1128
RELA--1142
MAPK8--1214
MAP2K20.2511240
MAP3K7--1275
ATF2--1309
FOS--1680
MAPK11--1962
ELK1--2032
MAPK9--2237
DUSP6--2466
MEF2A--2837
ITCH--2932
PELI2--3014
PELI1--3259
MAP3K1--13381
TAB3--3641
MAPKAPK2--3870
MAPK14--3975
DUSP4--4019
IRF3--4175
MAPK7--4384
TNFAIP3--4469
CYLD--14624
HSPD1--14908
NFKBIA--5569
MAP2K7--5837
MAPK30.2516426
UBC--6756
TAB1--7218
DUSP3--8506
DUSP7--8625
MAP2K6--10478
TBK1--10660
TLR6--10981
COLEC12--10987
UBE2V1--11027
TRAF3--11036
TRAF6--11055
TLR10--11746
TLR4--112795
TLR7--13389
MAP2K3--13704
IRAK3--14633
IRAK2--15024
NFKB2--15507
CLEC7A--115738
TLR2--119246
UBB--19448
IKBKB--20225
NFKB1--20281
TLR5--20283
TIRAP--20658
CD86--20696
RIPK2--20830
NOD2--121514
TLR1--21623
IRAK1--21640
TICAM1--21880
MARCO--22113
BCL10--122368
TLR3--22478
RIPK1--22681
NFKBIB--22875
MYD88--23106
IRAK4--23154
RPS6KA1--23184
LY96--23247
NOD1--23388
IKBKG--123539
CARD9--123577
UNC93B1--23927
MAPKAPK3--24170
ATF1--24277
RPS27A--24381
UBA52--24384
IRF7--24488
DMBT1--24546
CASP8--124587
IKBKE--24643
CHUK--24756
CDK1--25053
S100A14--25078
TICAM2--25440

Network

GO:0002221

Network
Enrichment
NameDescriptionExternal IDs
CREB1cAMP responsive element binding protein 1 Entrez:1385  HGNC: 2345  HPRD: 00442  Ensembl: ENSG00000118260 
MAPK10mitogen-activated protein kinase 10 Entrez:5602  HGNC: 6872  Ensembl: ENSG00000109339  HPRD: 04207 
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5 Entrez:9252  Ensembl: ENSG00000100784  HPRD: 06789  HGNC: 10434 
MEF2Cmyocyte enhancer factor 2C Entrez:4208  HGNC: 6996  Ensembl: ENSG00000081189  HPRD: 02809 
JUNjun proto-oncogene Entrez:3725  HGNC: 6204  HPRD: 01302  Ensembl: ENSG00000177606 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CREB1cAMP responsive element binding protein 1
MAPK10mitogen-activated protein kinase 10
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5
MEF2Cmyocyte enhancer factor 2C
JUNjun proto-oncogene
Query geneGeneGene descriptionEdge score
CREB1CREB1cAMP responsive element binding protein 1
MAPK10MAPK10mitogen-activated protein kinase 10
RPS6KA5RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5
MEF2CMEF2Cmyocyte enhancer factor 2C
JUNJUNjun proto-oncogene

Troyanskaya Laboratory - Princeton University