ASD

GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway (14)

GeneInput weightStandardRank
CAMK2B0.25155
GRM50.251240
DRD20.2513749
DRD30.2514349
GRK4--4632
ADRBK1--6028
HTR2B--6992
HTR1B0.2518092
GIPR--10369
ARRB2--10647
ARRB1--19906
PLD2--22908
ADRB20.25123251
GTF2H2--25399

Network

GO:0002029

Network
Enrichment
NameDescriptionExternal IDs
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta Entrez:816  Ensembl: ENSG00000058404  HGNC: 1461  HPRD: 12127 
GRM5glutamate receptor, metabotropic 5 Entrez:2915  HGNC: 4597  Ensembl: ENSG00000168959 
DRD2dopamine receptor D2 Entrez:1813  HPRD: 00539  Ensembl: ENSG00000149295  HGNC: 3023 
DRD3dopamine receptor D3 Entrez:1814  HGNC: 3024  Ensembl: ENSG00000151577  HPRD: 00540 
GRK4G protein-coupled receptor kinase 4 Entrez:2868  Ensembl: ENSG00000125388  HGNC: 4543  HPRD: 00656 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta
GRM5glutamate receptor, metabotropic 5
DRD2dopamine receptor D2
DRD3dopamine receptor D3
GRK4G protein-coupled receptor kinase 4
Query geneGeneGene descriptionEdge score
CAMK2BCAMK2Bcalcium/calmodulin-dependent protein kinase II beta
GRM5GRM5glutamate receptor, metabotropic 5
DRD2DRD2dopamine receptor D2
DRD3DRD3dopamine receptor D3
GRK4GRK4G protein-coupled receptor kinase 4

Troyanskaya Laboratory - Princeton University