ASD

GO:0070302 regulation of stress-activated protein kinase signaling cascade (113)

GeneInput weightStandardRank
PLCB1--148
GRIK20.51232
RAP2A--324
MAPK8IP2--418
MAP3K9--462
SPAG9--558
MAP4K4--565
MAPK8IP1--1605
TGFB2--834
NCOR1--1019
AKT10.2511020
HIPK2--1051
CDC42--1138
COPS5--1158
GAB1--1198
MAP3K5--1220
MAP3K7--1275
SEMA4C--1304
TAOK1--1336
FZD7--1357
TAOK20.2511633
PKN1--1967
DVL3--2090
MID1--2259
MAPK8IP3--2274
PDCD4--2707
MAP4K5--2894
ITCH--2932
FZD10--2957
MAP3K10--2968
PTK2B--3063
MAP3K2--3184
WNT5A--3319
MAP3K1--13381
TAOK3--3466
DAB2IP--3482
MAP3K4--3663
DIXDC1--3734
AKT2--13912
FOXO10.2513947
WNT16--4117
AXIN1--14419
TRAF4--4556
IL1A--4651
MEN1--14917
PAK1--4940
EDA2R--4972
MECOM--4979
CBS0.2515018
DUSP10--5172
TNFRSF11A--15293
MAP2K7--5837
DUSP19--6060
ZEB2--6361
DVL2--6546
WNT7B--7113
SFRP4--7310
WNT7A--7312
FGD4--17457
PPEF2--7509
HIPK3--8282
DUSP3--8506
DAXX--8508
GSTP10.2518742
EDN1--9540
LYN--10336
IL1B--110818
TLR6--10981
TRAF6--11055
IL26--11645
ZNF675--11676
FGF19--12130
SH3RF1--12767
MAP3K11--12938
TLR9--13360
MDFI--13519
CCL19--14578
TNF0.25115243
GPS2--17956
TP73--18810
BIRC7--19826
SDCBP--19967
F2RL1--19969
AMBP--20003
PTPLAD1--20272
FKTN--120500
MAP4K2--20522
TIRAP--20658
RIPK2--20830
NOD2--121514
MDFIC--21692
HDAC3--21702
CCL21--21829
MAP4K1--22336
CCR7--22367
DBNL--22402
NBR1--22425
TLR3--22478
TPD52L1--22519
RIPK1--22681
CD27--22836
MUL1--22953
MYD88--23106
NOD1--23388
CARD9--123577
TRAF2--23686
SYK--23906
MAP3K6--24220
DUSP22--24825
IGBP1--25127
AIDA--25211
IL1RN0.25125385
FOXM1--25656

Network

GO:0070302

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
RAP2ARAP2A, member of RAS oncogene family Entrez:5911  HGNC: 9861  HPRD: 01547 
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2 Entrez:23542  HPRD: 09674  Ensembl: ENSG00000008735  HGNC: 6883 
MAP3K9mitogen-activated protein kinase kinase kinase 9 Entrez:4293  Ensembl: ENSG00000006432  HGNC: 6861  HPRD: 15965 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIK2glutamate receptor, ionotropic, kainate 2
RAP2ARAP2A, member of RAS oncogene family
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2
MAP3K9mitogen-activated protein kinase kinase kinase 9
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2
RAP2ARAP2ARAP2A, member of RAS oncogene family
MAPK8IP2MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2
MAP3K9MAP3K9mitogen-activated protein kinase kinase kinase 9

Troyanskaya Laboratory - Princeton University