ASD

GO:0071902 positive regulation of protein serine/threonine kinase activity (176)

GeneInput weightStandardRank
PPP2CA--20
KRAS--157
HTR2A0.251121
MAP3K9--462
SPAG9--558
CDK5R1--586
SNCA--1667
MADD--759
CCND2--782
TAB2--785
MAP2K10.251907
GNG3--927
GRM10.251975
PROX1--997
AKT10.2511020
MAPK1--1128
GAB1--1198
MAP3K5--1220
MAP2K20.2511240
PDCD10--1274
MAP3K7--1275
ADRA2A0.2511399
SPRY2--1454
EDN3--11577
ZFP91--1788
CHRNA70.511837
TGFA--1873
MAPK11--1962
PKN1--1967
DVL3--2090
MAPK8IP3--2274
STK4--2276
PSMD10--2412
EGFR--12546
SOD1--12702
MAP4K5--2894
FZD10--2957
MAP3K10--2968
PTK2B--3063
MAP3K2--3184
WNT5A--3319
MAP3K1--13381
DAB2IP--3482
TAB3--3641
MAP3K4--3663
PDGFA--3731
NOX4--3804
MAPKAPK2--3870
MAPK14--3975
VEGFA0.2514087
PDE6H--4126
LPAR1--4170
AXIN1--14419
FGF10--14532
PROK2--14655
PAK1--4940
TNFRSF11A--15293
HGF0.2515313
ADAM17--5323
CXCR4--5414
PRDX2--5497
MAP2K7--5837
INSR--15872
ADIPOQ0.2516032
PLA2G1B--6059
DUSP19--6060
TDGF1--6132
ALS2--16326
ZEB2--6361
MAPK30.2516426
LPAR2--6450
DVL2--6546
UBC--6756
TNFSF15--6782
PLCE1--6929
HTR2B--6992
DRD40.2517021
WNT7B--7113
FRS2--7173
TAB1--7218
ILK--7305
WNT7A--7312
GRM4--7321
FGD4--17457
GH1--7858
CCND1--17970
MET1.018002
CD24--18102
DAXX--8508
ADRA2C--8551
PROK1--9002
PIM1--9182
GHRL0.2519242
EDN1--9540
C1QTNF2--10034
SHC1--10045
GHR--110098
ADRA2B--10119
MAP2K6--10478
CCNY--10662
IL1B--110818
TLR6--10981
TRAF6--11055
PIK3CB--11542
LPAR3--11897
CD81--112160
EPGN--12503
TLR4--112795
EGF0.25112881
MAP3K11--12938
TGFB3--113097
FGF2--13150
TLR9--13360
MDFI--13519
MALT1--13522
TNFRSF10B--13570
MAP2K3--13704
RPTOR--14284
CARD14--14340
CCL19--14578
IRAK2--15024
TNF0.25115243
ITGA1--15500
ELANE--115526
AJUBA--18146
PSEN1--18523
TP73--18810
IQGAP3--19438
UBB--19448
ADORA2B--19522
BIRC7--19826
HSPA2--20026
TGFB10.25120135
PTPLAD1--20272
PDE6G--120364
MAP4K2--20522
RIPK2--20830
PDGFB--21071
SLC27A1--21124
CCND3--21136
STK3--21167
C5AR1--21363
FPR1--21375
EFNA1--21477
NOD2--121514
IRAK1--21640
MDFIC--21692
TNFRSF10A--21740
ADAM8--21797
C5--122004
MAP4K1--22336
IGF20.25122401
DBNL--22402
TLR3--22478
TPD52L1--22519
S1PR2--22592
RIPK1--22681
PRKAA1--22917
MUL1--22953
ERBB2--123130
PDGFRB--23242
NOD1--23388
IKBKG--123539
TRAF2--23686
AVPI1--23843
CARD10--23869
SYK--23906
CD74--24030
MAPKAPK3--24170
MAP3K6--24220
RPS27A--24381
UBA52--24384
THBS1--24444
ACSL1--24993
CDK1--25053
IL1RN0.25125385

Network

GO:0071902

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
MAP3K9mitogen-activated protein kinase kinase kinase 9 Entrez:4293  Ensembl: ENSG00000006432  HGNC: 6861  HPRD: 15965 
SPAG9sperm associated antigen 9 Entrez:9043  HPRD: 10398  HGNC: 14524  Ensembl: ENSG00000008294 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
KRASKirsten rat sarcoma viral oncogene homolog
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
MAP3K9mitogen-activated protein kinase kinase kinase 9
SPAG9sperm associated antigen 9
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
KRASKRASKirsten rat sarcoma viral oncogene homolog
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
MAP3K9MAP3K9mitogen-activated protein kinase kinase kinase 9
SPAG9SPAG9sperm associated antigen 9

Troyanskaya Laboratory - Princeton University