ASD

GO:0007271 synaptic transmission, cholinergic (19)

GeneInput weightStandardRank
CHRNA3--1266
CHRNB3--1598
CHRNA70.511837
SPECC1L--1912
ACHE--2025
SLC5A7--2703
BCHE--2809
CHRNA40.2514471
CHRNB4--4903
COLQ--6220
ADORA2A0.2518408
CHRNA10--10096
CHRNE--10373
CHRNB20.25120216
RAPSN--20521
CHRFAM7A--20694
CHRNB1--21815
APOE0.25123516
NQO1--25542

Network

GO:0007271

Network
Enrichment
NameDescriptionExternal IDs
CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal) Entrez:1136  HGNC: 1957  HPRD: 07511  Ensembl: ENSG00000080644 
CHRNB3cholinergic receptor, nicotinic, beta 3 (neuronal) Entrez:1142  HGNC: 1963  Ensembl: ENSG00000147432  HPRD: 00336 
CHRNA7cholinergic receptor, nicotinic, alpha 7 (neuronal) Entrez:1139  HPRD: 00339  HGNC: 1960 
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1-like Entrez:23384  HPRD: 11080  HGNC: 29022  Ensembl: ENSG00000100014 
ACHEacetylcholinesterase Entrez:43  HGNC: 108  Ensembl: ENSG00000087085  HPRD: 00010 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB3cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNA7cholinergic receptor, nicotinic, alpha 7 (neuronal)
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1-like
ACHEacetylcholinesterase
Query geneGeneGene descriptionEdge score
CHRNA3CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB3CHRNB3cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNA7CHRNA7cholinergic receptor, nicotinic, alpha 7 (neuronal)
SPECC1LSPECC1Lsperm antigen with calponin homology and coiled-coil domains 1-like
ACHEACHEacetylcholinesterase

Troyanskaya Laboratory - Princeton University