ASD

GO:0060795 cell fate commitment involved in formation of primary germ layers (20)

GeneInput weightStandardRank
SOX2--1200
PAX2--653
SMAD1--1872
NODAL--13149
KLF4--3609
SOX17--4024
NANOG--4083
HOXA11--4432
WNT3A--4747
EYA2--6194
SIX2--6306
BMP4--16499
WNT8A--7814
CTNNB10.519066
TDGF1P3--9765
FOXC2--10175
FOXC1--113793
POU5F1--19704
FOXS1--20143
TRIM15--21614

Network

GO:0060795

Network
Enrichment
NameDescriptionExternal IDs
SOX2SRY (sex determining region Y)-box 2 Entrez:6657  HGNC: 11195  HPRD: 08921  Ensembl: ENSG00000181449 
PAX2paired box 2 Entrez:5076  HGNC: 8616  Ensembl: ENSG00000075891  HPRD: 01330 
SMAD1SMAD family member 1 Entrez:4086  Ensembl: ENSG00000170365  HGNC: 6767  HPRD: 03356 
NODALnodal growth differentiation factor Entrez:4838  HGNC: 7865  HPRD: 08370 
KLF4Kruppel-like factor 4 (gut) Entrez:9314  HGNC: 6348  Ensembl: ENSG00000136826 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SOX2SRY (sex determining region Y)-box 2
PAX2paired box 2
SMAD1SMAD family member 1
NODALnodal growth differentiation factor
KLF4Kruppel-like factor 4 (gut)
Query geneGeneGene descriptionEdge score
SOX2SOX2SRY (sex determining region Y)-box 2
PAX2PAX2paired box 2
SMAD1SMAD1SMAD family member 1
NODALNODALnodal growth differentiation factor
KLF4KLF4Kruppel-like factor 4 (gut)

Troyanskaya Laboratory - Princeton University