ASD

GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway (43)

GeneInput weightStandardRank
ADCY2--175
SSTR2--251
ADCY10.251466
APLP1--591
GNAZ--856
ADORA1--960
OPRK10.251996
NPY2R0.2511024
GNAL--1177
NPY1R0.2511190
GRIK30.2511247
GNAI3--1262
ADRA2A0.2511399
GNAI1--1468
ADCY9--1850
ADCY8--2785
ADCY6--2877
MCHR10.2512905
HTR1A0.2513315
CHRM50.2513694
DRD20.2513749
FLNA--14285
ADCY5--4295
S1PR1--4301
P2RY1--4342
DRD30.2514349
NPR3--5370
CHRM4--5408
ADCY3--5755
GNAI2--5860
RXFP2--15887
OPRD10.2516030
OPRL10.2516271
S1PR3--6774
DRD40.2517021
GRM4--7321
ADCY4--9091
RGS1--10535
PTGDR2--10914
CORT--12689
SSTR50.25114876
INSL3--119059
ADCY7--25408

Network

GO:0007193

Network
Enrichment
NameDescriptionExternal IDs
ADCY2adenylate cyclase 2 (brain) Entrez:108  HGNC: 233  HPRD: 00052  Ensembl: ENSG00000078295 
SSTR2somatostatin receptor 2 Entrez:6752  HPRD: 01674  HGNC: 11331 
ADCY1adenylate cyclase 1 (brain) Entrez:107  HGNC: 232  HPRD: 00053  Ensembl: ENSG00000164742 
APLP1amyloid beta (A4) precursor-like protein 1 Entrez:333  HGNC: 597  HPRD: 00102  Ensembl: ENSG00000105290 
GNAZguanine nucleotide binding protein (G protein), alpha z polypeptide Entrez:2781  HPRD: 00746  HGNC: 4395  Ensembl: ENSG00000128266 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
ADCY2adenylate cyclase 2 (brain)
SSTR2somatostatin receptor 2
ADCY1adenylate cyclase 1 (brain)
APLP1amyloid beta (A4) precursor-like protein 1
GNAZguanine nucleotide binding protein (G protein), alpha z polypeptide
Query geneGeneGene descriptionEdge score
ADCY2ADCY2adenylate cyclase 2 (brain)
SSTR2SSTR2somatostatin receptor 2
ADCY1ADCY1adenylate cyclase 1 (brain)
APLP1APLP1amyloid beta (A4) precursor-like protein 1
GNAZGNAZguanine nucleotide binding protein (G protein), alpha z polypeptide

Troyanskaya Laboratory - Princeton University