ASD

GO:0090090 negative regulation of canonical Wnt receptor signaling pathway (57)

GeneInput weightStandardRank
SOX2--1200
APC0.251266
SFRP1--387
SOX9--1970
APC2--1115
AES--1230
HDAC2--1440
LEF1--1499
LRP4--1500
MCC--2167
STK4--2276
DKK2--2331
LATS1--2781
CTNND1--2948
EGR1--3062
WNT5A--3319
DAB2IP--3482
TCF7L20.513548
SIAH2--3729
SOX17--4024
AXIN2--14260
AXIN1--14419
CYLD--14624
DRAXIN--4717
SFRP2--5252
DKK3--5413
PRICKLE1--15552
GLI1--6241
GLI3--16261
TLE2--6532
SOST--6885
SCYL2--7130
SFRP4--7310
WNT11--7820
FRZB--8105
GPC3--18430
NKX2-50.2518486
TBX18--8991
LATS2--9736
SFRP5--11273
DKK1--11567
NPHP3--113474
MESP1--13805
INVS--114708
DDIT3--14883
WNT5B--15534
SHH--118571
FZD6--19921
FZD1--20775
STK3--21167
WNT4--21809
PFDN5--23272
CBY1--23816
SNAI2--123962
WWTR1--24317
DAB2--25338
CAV1--125381

Network

GO:0090090

Network
Enrichment
NameDescriptionExternal IDs
SOX2SRY (sex determining region Y)-box 2 Entrez:6657  HGNC: 11195  HPRD: 08921  Ensembl: ENSG00000181449 
APCadenomatous polyposis coli Entrez:324  HGNC: 583  HPRD: 01439  Ensembl: ENSG00000134982 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
SOX9SRY (sex determining region Y)-box 9 Entrez:6662  HPRD: 06427  HGNC: 11204  Ensembl: ENSG00000125398 
APC2adenomatosis polyposis coli 2 Entrez:10297  Ensembl: ENSG00000115266  HGNC: 24036  HPRD: 09802 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SOX2SRY (sex determining region Y)-box 2
APCadenomatous polyposis coli
SFRP1secreted frizzled-related protein 1
SOX9SRY (sex determining region Y)-box 9
APC2adenomatosis polyposis coli 2
Query geneGeneGene descriptionEdge score
SOX2SOX2SRY (sex determining region Y)-box 2
APCAPCadenomatous polyposis coli
SFRP1SFRP1secreted frizzled-related protein 1
SOX9SOX9SRY (sex determining region Y)-box 9
APC2APC2adenomatosis polyposis coli 2

Troyanskaya Laboratory - Princeton University