ASD

GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway (26)

GeneInput weightStandardRank
CAMK2B0.25155
GRM50.251240
SNCA--1667
ADRA2A0.2511399
PALM--1501
MGRN1--2277
DRD20.2513749
RGS12--3946
DRD30.2514349
GRK4--4632
RGS2--5095
ADRBK1--6028
RGS13--6883
HTR2B--6992
HTR1B0.2518092
RPH3AL--8235
GIPR--10369
ARRB2--10647
KLK14--19554
ARRB1--19906
RPGRIP1L--21472
PLD2--22908
ADRB20.25123251
PLEK--24240
ADA0.5124751
GTF2H2--25399

Network

GO:0045744

Network
Enrichment
NameDescriptionExternal IDs
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta Entrez:816  Ensembl: ENSG00000058404  HGNC: 1461  HPRD: 12127 
GRM5glutamate receptor, metabotropic 5 Entrez:2915  HGNC: 4597  Ensembl: ENSG00000168959 
SNCAsynuclein, alpha (non A4 component of amyloid precursor) Entrez:6622  HPRD: 01227  HGNC: 11138  Ensembl: ENSG00000145335 
ADRA2Aadrenoceptor alpha 2A Entrez:150  HGNC: 281  HPRD: 00078  Ensembl: ENSG00000150594 
PALMparalemmin Entrez:5064  HGNC: 8594  Ensembl: ENSG00000099864  HPRD: 09734 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta
GRM5glutamate receptor, metabotropic 5
SNCAsynuclein, alpha (non A4 component of amyloid precursor)
ADRA2Aadrenoceptor alpha 2A
PALMparalemmin
Query geneGeneGene descriptionEdge score
CAMK2BCAMK2Bcalcium/calmodulin-dependent protein kinase II beta
GRM5GRM5glutamate receptor, metabotropic 5
SNCASNCAsynuclein, alpha (non A4 component of amyloid precursor)
ADRA2AADRA2Aadrenoceptor alpha 2A
PALMPALMparalemmin

Troyanskaya Laboratory - Princeton University