ASD

GO:0048015 phosphatidylinositol-mediated signaling (84)

GeneInput weightStandardRank
CREB1--100
PIK3R10.251150
IGF1R--252
PHLPP1--332
GSK3B--427
RICTOR--537
AKT10.2511020
FOXO3--1056
CDKN1B--1162
PI4KA--1242
BAD--1290
IRS2--11300
PIK3CA0.2511362
IRS1--11374
PTEN1.011389
RPS6KB1--1521
PDPK1--1740
PI4KB--2004
PLCH1--2174
RHOA--2292
NCS1--2628
PCNA--2671
IGF10.2512793
CKS2--3213
HMGB2--3362
GAB2--3496
PIK3C2G--3730
PI4KAP1--3784
FOXO10.2513947
GSK3A--4141
PIK3C2A--4475
GPR143--14685
MLST8--5028
PIK3R2--5198
HIST1H4C--5314
PIK3C2B--5320
HIST1H4F--5483
NGF0.2516229
MDM2--6675
HIST1H4B--7028
CA8--7267
CDKN1A--7714
NTRK10.2518522
HIST1H4A--8765
HIST1H4E--8846
HIST4H4--9288
TSC20.2519351
PIK3C3--9358
FOXO4--9362
HIST1H4I--9593
PIK3CG0.25110306
PI4KAP2--10862
HIST1H4K--11490
PIK3CB--11542
HIST1H4H--11835
HIST2H4B--12217
HIST1H4L--12237
NR4A1--12498
AKT1S1--13569
HIST1H4D--15824
ZP3--17443
MAPKAP1--20094
TRIB3--20863
CASP90.25121044
MTOR--21095
HIST1H4J--21464
PIK3CD--21578
HIST2H4A--22838
ERBB2--123130
RPS6KB2--23226
NDC80--23746
RFC4--23796
GSN--124007
THEM4--24011
CHUK--24756
TOP2A--24765
PTAFR--24788
ZWINT--25100
TYMS--25226
SPAG5--25573
UBE2C--25614
FEN1--25667
BUB1B--125766
AURKA--125772

Network

GO:0048015

Network
Enrichment
NameDescriptionExternal IDs
CREB1cAMP responsive element binding protein 1 Entrez:1385  HGNC: 2345  HPRD: 00442  Ensembl: ENSG00000118260 
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Entrez:5295  HGNC: 8979  Ensembl: ENSG00000145675  HPRD: 01381 
IGF1Rinsulin-like growth factor 1 receptor Entrez:3480  Ensembl: ENSG00000140443  HPRD: 00932  HGNC: 5465 
PHLPP1PH domain and leucine rich repeat protein phosphatase 1 Entrez:23239  HGNC: 20610  HPRD: 15145  Ensembl: ENSG00000081913 
GSK3Bglycogen synthase kinase 3 beta Entrez:2932  Ensembl: ENSG00000082701  HPRD: 05418  HGNC: 4617 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CREB1cAMP responsive element binding protein 1
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
IGF1Rinsulin-like growth factor 1 receptor
PHLPP1PH domain and leucine rich repeat protein phosphatase 1
GSK3Bglycogen synthase kinase 3 beta
Query geneGeneGene descriptionEdge score
CREB1CREB1cAMP responsive element binding protein 1
PIK3R1PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
IGF1RIGF1Rinsulin-like growth factor 1 receptor
PHLPP1PHLPP1PH domain and leucine rich repeat protein phosphatase 1
GSK3BGSK3Bglycogen synthase kinase 3 beta

Troyanskaya Laboratory - Princeton University