ASD

GO:0048025 negative regulation of nuclear mRNA splicing, via spliceosome (8)

GeneInput weightStandardRank
SRSF10--1221
SRSF4--1403
SRSF9--1459
PTBP1--1894
SRSF12--3143
SRSF7--3293
SRSF6--7591
U2AF2--15462

Network

GO:0048025

Network
Enrichment
NameDescriptionExternal IDs
SRSF10serine/arginine-rich splicing factor 10 Entrez:10772  HGNC: 16713  HPRD: 05562  Ensembl: ENSG00000188529 
SRSF4serine/arginine-rich splicing factor 4 Entrez:6429  Ensembl: ENSG00000116350  HGNC: 10786  HPRD: 09052 
SRSF9serine/arginine-rich splicing factor 9 Entrez:8683  HPRD: 09053  Ensembl: ENSG00000111786  HGNC: 10791 
PTBP1polypyrimidine tract binding protein 1 Entrez:5725  HGNC: 9583  Ensembl: ENSG00000011304  HPRD: 02823 
SRSF12serine/arginine-rich splicing factor 12 Entrez:135295  Ensembl: ENSG00000154548  HPRD: 11605  HGNC: 21220 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SRSF10serine/arginine-rich splicing factor 10
SRSF4serine/arginine-rich splicing factor 4
SRSF9serine/arginine-rich splicing factor 9
PTBP1polypyrimidine tract binding protein 1
SRSF12serine/arginine-rich splicing factor 12
Query geneGeneGene descriptionEdge score
SRSF10SRSF10serine/arginine-rich splicing factor 10
SRSF4SRSF4serine/arginine-rich splicing factor 4
SRSF9SRSF9serine/arginine-rich splicing factor 9
PTBP1PTBP1polypyrimidine tract binding protein 1
SRSF12SRSF12serine/arginine-rich splicing factor 12

Troyanskaya Laboratory - Princeton University