ASD

GO:0045862 positive regulation of proteolysis (58)

GeneInput weightStandardRank
EP300--1318
SUMO1--1411
TRIB2--472
OGT--477
CNTN2--674
CSNK1D--699
MGEA5--732
CSNK1E0.251752
FBXW11--859
AKT10.2511020
SMAD7--1192
PTEN1.011389
ADRA2A0.2511399
HDAC2--1440
RCHY1--1615
BTRC--1884
UBE2V2--1939
PSMD10--2412
TRIB1--3431
SUMO2--4064
STUB1--4250
RNF180--4255
FURIN--4605
PRICKLE1--15552
DNAJB2--6026
MDM2--6675
SH3D19--6906
VCP--7434
C6--8602
LRRK2--18802
HSPBP1--9785
TRIM320.2519794
USP5--9852
TAF1--10729
IL1B--110818
GCLC--12360
IFT88--12504
WFS10.25112793
IFNG--112827
KLKB1--12910
AURKAIP1--14217
TNF0.25115243
IFT52--16599
PSEN1--18523
PACSIN3--21093
F12--121126
NRD1--21456
NUB1--21779
ADAM8--21797
GNB2L1--23282
APOE0.25123516
FBXO22--23669
CLN6--124022
PLGRKT--25130
ADAM9--125221
DAB2--25338
CLU--25437
PLK1--25783

Network

GO:0045862

Network
Enrichment
NameDescriptionExternal IDs
EP300E1A binding protein p300 Entrez:2033  Ensembl: ENSG00000100393  HGNC: 3373  HPRD: 04078 
SUMO1small ubiquitin-like modifier 1 Entrez:7341  Ensembl: ENSG00000116030  HGNC: 12502  HPRD: 03554 
TRIB2tribbles homolog 2 (Drosophila) Entrez:28951  HPRD: 18224  HGNC: 30809  Ensembl: ENSG00000071575 
OGTO-linked N-acetylglucosamine (GlcNAc) transferase Entrez:8473  HGNC: 8127  Ensembl: ENSG00000147162  HPRD: 02222 
CNTN2contactin 2 (axonal) Entrez:6900  HGNC: 2172  Ensembl: ENSG00000184144  HPRD: 01826 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
EP300E1A binding protein p300
SUMO1small ubiquitin-like modifier 1
TRIB2tribbles homolog 2 (Drosophila)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase
CNTN2contactin 2 (axonal)
Query geneGeneGene descriptionEdge score
EP300EP300E1A binding protein p300
SUMO1SUMO1small ubiquitin-like modifier 1
TRIB2TRIB2tribbles homolog 2 (Drosophila)
OGTOGTO-linked N-acetylglucosamine (GlcNAc) transferase
CNTN2CNTN2contactin 2 (axonal)

Troyanskaya Laboratory - Princeton University