ASD

GO:0007215 glutamate signaling pathway (26)

GeneInput weightStandardRank
PLCB1--148
GRIN2A0.25166
GRIA30.25178
GNAQ--189
GRIK20.51232
GRM50.251240
GRIN1--294
GRIK1--481
CDK5R1--586
GRIN2B1.01763
ATP1A3--1236
GRIK30.2511247
GRIA4--1474
APP--1515
SSTR1--1959
GRM6--12585
HOMER3--2587
GRID20.2513225
GRIN3A--3242
HOMER10.2513402
GRIK4--4875
GRIN2C--5801
GRM4--7321
GRIN3B--7952
CLN3--110442
HOMER2--14699

Network

GO:0007215

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A Entrez:2903  HGNC: 4585  Ensembl: ENSG00000183454  HPRD: 00698 
GRIA3glutamate receptor, ionotropic, AMPA 3 Entrez:2892  Ensembl: ENSG00000125675  HGNC: 4573  HPRD: 02378 
GNAQguanine nucleotide binding protein (G protein), q polypeptide Entrez:2776  HGNC: 4390  HPRD: 02998 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIA3glutamate receptor, ionotropic, AMPA 3
GNAQguanine nucleotide binding protein (G protein), q polypeptide
GRIK2glutamate receptor, ionotropic, kainate 2
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIN2AGRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIA3GRIA3glutamate receptor, ionotropic, AMPA 3
GNAQGNAQguanine nucleotide binding protein (G protein), q polypeptide
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2

Troyanskaya Laboratory - Princeton University