ASD

GO:0030901 midbrain development (28)

GeneInput weightStandardRank
FGFR2--1237
LRP6--279
RFX4--1148
SMAD1--1872
OTX2--11916
EN20.2511984
FGFR1--2262
MSX1--13127
FZD3--3193
SMAD9--13672
WNT1--4383
JHDM1D--4566
OTX1--4602
EN1--5021
NDST1--5114
FOXB1--5360
BARHL1--5649
HES10.2515912
UQCRQ--6404
GDF7--6682
HES3--7466
KDM2B--8359
TAL2--8785
SHH--118571
PITX30.25119326
FZD6--19921
KAT2A--21262
UCHL5--22745

Network

GO:0030901

Network
Enrichment
NameDescriptionExternal IDs
FGFR2fibroblast growth factor receptor 2 Entrez:2263  HPRD: 01492  Ensembl: ENSG00000066468  HGNC: 3689 
LRP6low density lipoprotein receptor-related protein 6 Entrez:4040  Ensembl: ENSG00000070018  HGNC: 6698  HPRD: 04617 
RFX4regulatory factor X, 4 (influences HLA class II expression) Entrez:5992  Ensembl: ENSG00000111783  HGNC: 9985  HPRD: 04905 
SMAD1SMAD family member 1 Entrez:4086  Ensembl: ENSG00000170365  HGNC: 6767  HPRD: 03356 
OTX2orthodenticle homeobox 2 Entrez:5015  HGNC: 8522  HPRD: 07190  Ensembl: ENSG00000165588 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
FGFR2fibroblast growth factor receptor 2
LRP6low density lipoprotein receptor-related protein 6
RFX4regulatory factor X, 4 (influences HLA class II expression)
SMAD1SMAD family member 1
OTX2orthodenticle homeobox 2
Query geneGeneGene descriptionEdge score
FGFR2FGFR2fibroblast growth factor receptor 2
LRP6LRP6low density lipoprotein receptor-related protein 6
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)
SMAD1SMAD1SMAD family member 1
OTX2OTX2orthodenticle homeobox 2

Troyanskaya Laboratory - Princeton University