ASD

GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process (46)

GeneInput weightStandardRank
UBR5--193
SIAH1--223
UBE3A0.251365
NEDD4L--495
RBBP6--879
HECW1--882
SMURF2--889
PARK20.251952
HECTD2--988
FBXL14--1433
RCHY1--1615
HERC2--1632
HECTD4--1777
HERC4--1807
TRIP120.512064
UBE4B--2086
HECTD1--2762
LNX1--2878
ITCH--2932
HECW2--2991
MYLIP--3008
SMURF1--3060
HUWE1--3292
MAP3K1--13381
WWP1--3744
ARIH2--4649
HERC3--5537
RNF11--6141
MDM2--6675
UBE3C--7351
RNF146--7910
HACE1--8167
RNF217--9306
TRIM320.2519794
FBXO45--10684
AREL1--11551
WWP2--11885
NEDD40.25114040
HERC6--18813
DDB1--19185
UBE3B--19351
OS9--19622
HERC5--20857
CBLC--21497
RNF144B--23034
HECTD3--23477

Network

GO:0042787

Network
Enrichment
NameDescriptionExternal IDs
UBR5ubiquitin protein ligase E3 component n-recognin 5 Entrez:51366  HPRD: 06436  Ensembl: ENSG00000104517  HGNC: 16806 
SIAH1siah E3 ubiquitin protein ligase 1 Entrez:6477  Ensembl: ENSG00000196470  HGNC: 10857  HPRD: 03736 
UBE3Aubiquitin protein ligase E3A Entrez:7337  HPRD: 03375  HGNC: 12496  Ensembl: ENSG00000114062 
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Entrez:23327  HGNC: 7728  HPRD: 05903  Ensembl: ENSG00000049759 
RBBP6retinoblastoma binding protein 6 Entrez:5930  Ensembl: ENSG00000122257  HPRD: 02964  HGNC: 9889 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
UBR5ubiquitin protein ligase E3 component n-recognin 5
SIAH1siah E3 ubiquitin protein ligase 1
UBE3Aubiquitin protein ligase E3A
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
RBBP6retinoblastoma binding protein 6
Query geneGeneGene descriptionEdge score
UBR5UBR5ubiquitin protein ligase E3 component n-recognin 5
SIAH1SIAH1siah E3 ubiquitin protein ligase 1
UBE3AUBE3Aubiquitin protein ligase E3A
NEDD4LNEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
RBBP6RBBP6retinoblastoma binding protein 6

Troyanskaya Laboratory - Princeton University