ASD

GO:0010741 negative regulation of intracellular protein kinase cascade (90)

GeneInput weightStandardRank
PPP2CA--20
NEUROD1--1127
HGS--152
RGS4--178
IGF1R--252
APC0.251266
NF10.251372
DUSP8--438
MAPK8IP1--1605
SPRED2--811
SPRED1--962
NCOR1--1019
AKT10.2511020
PPP2R1A--1163
PTEN1.011389
SPRY2--1454
DUSP5--2022
GPS1--2023
PSMD10--2412
DUSP6--2466
IGF10.2512793
ITCH--2932
TAOK3--3466
DAB2IP--3482
DAG1--3580
KLF4--3609
DRD20.2513749
DUSP1--3785
PLEKHA1--3930
FOXO10.2513947
DUSP4--4019
DRD30.2514349
TNFAIP3--4469
MEN1--14917
MECOM--4979
DUSP10--5172
DUSP16--5189
OTUD7B--5199
NF2--15991
ADIPOQ0.2516032
DUSP19--6060
SFRP4--7310
PPEF2--7509
P2RX7--7888
PIN1--7940
DUSP3--8506
DUSP2--8596
DUSP7--8625
GSTP10.2518742
PTPRJ--19136
TSC20.2519351
SOCS1--9583
LAX1--10483
SPRY1--10636
SFRP5--11273
IRF1--111641
RHOC--11655
ZNF675--11676
SPRED3--12062
TLR4--112795
RGS14--12999
NFKBID--13229
DUSP9--13685
MBIP--14010
CAV3--115414
PEBP1--15772
RHOH--16137
GPS2--17956
CNKSR3--19160
EPHA2--119467
NDRG2--19677
NLRP12--19807
F2RL1--19969
AMBP--20003
VRK3--20233
FKTN--120500
HDAC3--21702
C9orf89--21822
SLC9A3R1--21898
LIF--22134
CARD8--22573
HNF4A--122965
RGS3--23349
DUSP22--24825
PHLDA3--24856
IGBP1--25127
AIDA--25211
CAV1--125381
DNAJA3--25610
FOXM1--25656

Network

GO:0010741

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
NEUROD1neuronal differentiation 1 Entrez:4760  HPRD: 03428  HGNC: 7762  Ensembl: ENSG00000162992 
HGShepatocyte growth factor-regulated tyrosine kinase substrate Entrez:9146  Ensembl: ENSG00000185359  HPRD: 05085  HGNC: 4897 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
IGF1Rinsulin-like growth factor 1 receptor Entrez:3480  Ensembl: ENSG00000140443  HPRD: 00932  HGNC: 5465 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
NEUROD1neuronal differentiation 1
HGShepatocyte growth factor-regulated tyrosine kinase substrate
RGS4regulator of G-protein signaling 4
IGF1Rinsulin-like growth factor 1 receptor
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
NEUROD1NEUROD1neuronal differentiation 1
HGSHGShepatocyte growth factor-regulated tyrosine kinase substrate
RGS4RGS4regulator of G-protein signaling 4
IGF1RIGF1Rinsulin-like growth factor 1 receptor

Troyanskaya Laboratory - Princeton University