ASD

GO:0000188 inactivation of MAPK activity (24)

GeneInput weightStandardRank
PPP2CA--20
RGS4--178
DUSP8--438
SPRED2--811
SPRED1--962
PPP2R1A--1163
DUSP5--2022
GPS1--2023
DUSP6--2466
DUSP1--3785
DUSP4--4019
DUSP10--5172
DUSP16--5189
DUSP3--8506
DUSP2--8596
DUSP7--8625
LAX1--10483
SPRED3--12062
DUSP9--13685
MBIP--14010
GPS2--17956
RGS3--23349
DUSP22--24825
CAV1--125381

Network

GO:0000188

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
DUSP8dual specificity phosphatase 8 Entrez:1850  Ensembl: ENSG00000184545  HGNC: 3074  HPRD: 03617 
SPRED2sprouty-related, EVH1 domain containing 2 Entrez:200734  Ensembl: ENSG00000198369  HGNC: 17722  HPRD: 18100 
SPRED1sprouty-related, EVH1 domain containing 1 Entrez:161742  HGNC: 20249  Ensembl: ENSG00000166068  HPRD: 11601 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
DUSP8dual specificity phosphatase 8
SPRED2sprouty-related, EVH1 domain containing 2
SPRED1sprouty-related, EVH1 domain containing 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
DUSP8DUSP8dual specificity phosphatase 8
SPRED2SPRED2sprouty-related, EVH1 domain containing 2
SPRED1SPRED1sprouty-related, EVH1 domain containing 1

Troyanskaya Laboratory - Princeton University